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Genome wide association study and genomic risk prediction of age related macular degeneration in Israel

التفاصيل البيبلوغرافية
العنوان: Genome wide association study and genomic risk prediction of age related macular degeneration in Israel
المؤلفون: Michelle Grunin, Daria Triffon, Gala Beykin, Elior Rahmani, Regev Schweiger, Liran Tiosano, Samer Khateb, Shira Hagbi-Levi, Batya Rinsky, Refael Munitz, Thomas W. Winkler, Iris M. Heid, Eran Halperin, Shai Carmi, Itay Chowers
المصدر: Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
بيانات النشر: Nature Portfolio, 2024.
سنة النشر: 2024
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Abstract The risk of developing age-related macular degeneration (AMD) is influenced by genetic background. In 2016, the International AMD Genomics Consortium (IAMDGC) identified 52 risk variants in 34 loci, and a polygenic risk score (PRS) from these variants was associated with AMD. The Israeli population has a unique genetic composition: Ashkenazi Jewish (AJ), Jewish non-Ashkenazi, and Arab sub-populations. We aimed to perform a genome-wide association study (GWAS) for AMD in Israel, and to evaluate PRSs for AMD. Our discovery set recruited 403 AMD patients and 256 controls at Hadassah Medical Center. We genotyped individuals via custom exome chip. We imputed non-typed variants using cosmopolitan and AJ reference panels. We recruited additional 155 cases and 69 controls for validation. To evaluate predictive power of PRSs for AMD, we used IAMDGC summary-statistics excluding our study and developed PRSs via clumping/thresholding or LDpred2. In our discovery set, 31/34 loci reported by IAMDGC were AMD-associated (P
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2045-2322
العلاقة: https://doaj.org/toc/2045-2322Test
DOI: 10.1038/s41598-024-63065-0
الوصول الحر: https://doaj.org/article/3409c3c4eb8c4bab900e2f3a3246f280Test
رقم الانضمام: edsdoj.3409c3c4eb8c4bab900e2f3a3246f280
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20452322
DOI:10.1038/s41598-024-63065-0