دورية أكاديمية
Prolonged enoxaparin therapy compared with standard-of-care antithrombotic therapy in opiate-treated patients undergoing primary percutaneous coronary intervention
| العنوان: | Prolonged enoxaparin therapy compared with standard-of-care antithrombotic therapy in opiate-treated patients undergoing primary percutaneous coronary intervention |
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| المؤلفون: | Wael Sumaya, William A.E. Parker, Heather M. Judge, Ian R. Hall, Rachel C. Orme, Zulfiquar Adam, James D. Richardson, Alexander M.K. Rothman, Kenneth P. Morgan, Julian P. Gunn, Robert F. Storey |
| المصدر: | Platelets, Vol 32, Iss 4, Pp 555-559 (2021) |
| بيانات النشر: | Taylor & Francis Group, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Diseases of the blood and blood-forming organs |
| مصطلحات موضوعية: | enoxaparin, glycoprotein iib/iiia inhibitors, p2y12 inhibitor, primary percutaneous coronary intervention, st-elevation myocardial infarction, unfractionated heparin, Diseases of the blood and blood-forming organs, RC633-647.5 |
| الوصف: | A novel enoxaparin regimen consisting of intra-arterial bolus (0.75 mg/kg) followed by intravenous infusion (0.75 mg/kg/6 hours) has been developed as a possible solution to the delayed absorption of oral P2Y12 inhibitors in opiate-treated ST-elevation myocardial infarction (STEMI) patients undergoing primary angioplasty. We aimed to study the feasibility of this regimen as an alternative to standard-of-care treatment (SOC) with unfractionated heparin ± glycoprotein IIb/IIIa antagonist (GPI). One hundred opiate-treated patients presenting with STEMI and accepted for primary angioplasty were randomized (1:1) to either enoxaparin or SOC. Fifty patients were allocated enoxaparin (median age 61, 40% females) and 49 allocated SOC (median age 62, 22% females). One developed stroke before angiography and was withdrawn. One SOC patient had a gastrointestinal bleed resulting in 1 g drop in hemoglobin and early cessation of GPI infusion. Two enoxaparin patients had transient minor bleeding: one transient gingival bleed and one episode of coffee ground vomit with no hemoglobin drop or hemodynamic instability. Two SOC and no enoxaparin group patients had acute stent thrombosis. These preliminary data support further study of this novel 6-hour enoxaparin regimen in opiate-treated PPCI patients. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0953-7104 1369-1635 09537104 |
| العلاقة: | https://doaj.org/toc/0953-7104Test; https://doaj.org/toc/1369-1635Test |
| DOI: | 10.1080/09537104.2020.1779925 |
| الوصول الحر: | https://doaj.org/article/3333115ba44f4ecd927f58c21aa5c9b6Test |
| رقم الانضمام: | edsdoj.3333115ba44f4ecd927f58c21aa5c9b6 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 09537104 13691635 |
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| DOI: | 10.1080/09537104.2020.1779925 |