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Causal relationship of interleukin-6 and its receptor on sarcopenia traits using mendelian randomization

التفاصيل البيبلوغرافية
العنوان: Causal relationship of interleukin-6 and its receptor on sarcopenia traits using mendelian randomization
المؤلفون: Baixing Chen, Shaoshuo Li, Shi Lin, Hang Dong
المصدر: Nutrition Journal, Vol 23, Iss 1, Pp 1-6 (2024)
بيانات النشر: BMC, 2024.
سنة النشر: 2024
المجموعة: LCC:Nutrition. Foods and food supply
LCC:Nutritional diseases. Deficiency diseases
مصطلحات موضوعية: Interleukin 6, IL-6 receptor, Sarcopenia, Genome-wide association studies, Mendelian randomization, Nutrition. Foods and food supply, TX341-641, Nutritional diseases. Deficiency diseases, RC620-627
الوصف: Abstract Background Previous research has extensively examined the role of interleukin 6 (IL-6) in sarcopenia. However, the presence of a causal relationship between IL-6, its receptor (IL-6R), and sarcopenia remains unclear. Method In this study, we utilized summary-level data from genome-wide association studies (GWAS) focused on appendicular lean mass (ALM), hand grip strength, and walking pace. Single nucleotide polymorphisms (SNPs) were employed as genetic instruments for IL-6 and IL-6R to estimate the causal effect of sarcopenia traits. We adopted the Mendelian randomization (MR) approach to investigate these associations using the inverse variance weighted (IVW) method as the primary analytical approach. Additionally, we performed sensitivity analyses to validate the reliability of the MR results. Result This study revealed a significant negative association between main IL-6R and eQTL IL-6R on the left grip strength were − 0.013 (SE = 0.004, p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1475-2891
العلاقة: https://doaj.org/toc/1475-2891Test
DOI: 10.1186/s12937-024-00958-w
الوصول الحر: https://doaj.org/article/3235a9ac72b54920b7a805c00e439609Test
رقم الانضمام: edsdoj.3235a9ac72b54920b7a805c00e439609
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14752891
DOI:10.1186/s12937-024-00958-w