| الوصف: |
Abstract Background Despite the increasing trend of cutaneous malignant melanoma (CMM) incidence in Canada, especially among females, few risk factors other than ultraviolet radiation exposure, have been identified. Aim We conducted a case–control study of 406 CMM cases and 181 controls to evaluate the potential impact of body burdens of various persistent organic pollutants on CMM risk. Methods Detailed data on potential confounding factors, including lifetime repeated sun exposure and skin reaction to repeated sun exposure, were collected. Gas chromatography tandem mass spectrometry was used to assay plasma levels of 14 polychlorinated biphenyl (PCB) congeners and 11 organochlorine (OC) pesticides among cases and controls. Results Statistically significant trends of increased CMM risk were observed with increasing plasma concentrations of multiple PCB congeners, including PCBs 138, 153, 170, 180, 183 and 187. For example, compared to lowest plasma concentration quartile of PCB‐138, the second, third and fourth quartiles were associated with 1.7 (95% CI: 0.9–2.9), 2.3 (95% CI: 1.3–4.1) and 2.4 (95% CI: 1.3–4.5) ‐fold increased risks of CMM, respectively. Similarly, increasing plasma concentrations of several OC pesticides (i.e., β‐HCH, HCB, Mirex, oxychlordane and trans‐Nonachlor) showed statistically significant trends with increased CMM risk. For example, compared to lowest plasma concentration quartile of β‐HCH, the second, third and fourth quartiles were associated with 1.3 (95% CI: 0.7–2.3), 2.1 (95% CI: 1.2–3.7) and 2.3 (95% CI: 1.2–4.4) ‐fold increased risks of CMM, respectively. Conclusion Plasma levels of several persistent organic pollutants were highly correlated, suggesting that observed associations were not necessarily independent of each other. Given the highly correlated nature of exposure to PCB and OC analytes, sophisticated analyses that consider complex mixtures should be considered in future studies. |
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