دورية أكاديمية
Fingolimod for the Treatment of Relapsing-Remitting Multiple Sclerosis
| العنوان: | Fingolimod for the Treatment of Relapsing-Remitting Multiple Sclerosis |
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| المؤلفون: | Burcu Altunrende, Erkingül Birday, Mithat Kasap, Gülşen Akman Demir |
| المصدر: | Türk Nöroloji Dergisi, Vol 23, Iss 4, Pp 176-185 (2017) |
| بيانات النشر: | Galenos Yayinevi, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Medicine LCC:Neurology. Diseases of the nervous system |
| مصطلحات موضوعية: | Multiple sclerosis, fingolimod, sphingosine-1 phosphate, efficacy, safety, Medicine, Neurology. Diseases of the nervous system, RC346-429 |
| الوصف: | Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system and is characterized by inflammation, demyelination, and axonal loss. Fingolimod is the first oral drug for the treatment of MS approved by the United States Food and Drug Administration, European Union countries, and various other countries. The compound exerts its effect via interaction with lysophospholipid receptors known as sphingosine-1 phosphate receptors. Although fingolimod has a very convenient daily oral dosing, it may cause development of bradycardia at the first dose, macular edema, infection, all of which require attention. Randomized double-blind clinical trials have shown that fingolimod significantly reduces relapse rates and is beneficial in brain magnetic resonance imaging measures when compared with both placebo and intramuscular interferon β-1a. This review describes the characteristics of fingolimod concerning its efficacy, safety, and tolerability in the clinical context of the management of MS |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1301-062X 1309-2545 |
| العلاقة: | http://www.tjn.org.tr/jvi.aspx?pdir=tjn&plng=eng&un=TJN-62144Test; https://doaj.org/toc/1301-062XTest; https://doaj.org/toc/1309-2545Test |
| DOI: | 10.4274/tnd.62144 |
| الوصول الحر: | https://doaj.org/article/2e0e55ded7ff4ac69f63f666b54929ceTest |
| رقم الانضمام: | edsdoj.2e0e55ded7ff4ac69f63f666b54929ce |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 1301062X 13092545 |
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| DOI: | 10.4274/tnd.62144 |