دورية أكاديمية
Serum Neurofilament Light Chain Levels Are Related to Small Vessel Disease Burden
| العنوان: | Serum Neurofilament Light Chain Levels Are Related to Small Vessel Disease Burden |
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| المؤلفون: | Marco Duering, Marek J. Konieczny, Steffen Tiedt, Ebru Baykara, Anil Man Tuladhar, Esther van Leijsen, Philippe Lyrer, Stefan T. Engelter, Benno Gesierich, Melanie Achmüller, Christian Barro, Ruth Adam, Michael Ewers, Martin Dichgans, Jens Kuhle, Frank-Erik de Leeuw, Nils Peters |
| المصدر: | Journal of Stroke, Vol 20, Iss 2, Pp 228-238 (2018) |
| بيانات النشر: | Korean Stroke Society, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Diseases of the circulatory (Cardiovascular) system |
| مصطلحات موضوعية: | biomarkers, serum, cerebral small vessel diseases, magnetic resonance imaging, dementia, vascular, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| الوصف: | Background and Purpose Neurofilament light chain (NfL) is a blood marker for neuroaxonal damage. We assessed the association between serum NfL and cerebral small vessel disease (SVD), which is highly prevalent in elderly individuals and a major cause of stroke and vascular cognitive impairment. Methods Using a cross-sectional design, we studied 53 and 439 patients with genetically defined SVD (Cerebral Autosomal-Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy [CADASIL]) and sporadic SVD, respectively, as well as 93 healthy controls. Serum NfL was measured by an ultrasensitive single-molecule array assay. We quantified magnetic resonance imaging (MRI) markers of SVD, i.e., white matter hyperintensity volume, lacune volume, brain volume, microbleed count, and mean diffusivity obtained from diffusion tensor imaging. Clinical characterization included neuropsychological testing in both SVD samples. CADASIL patients were further characterized for focal neurological deficits (National Institutes of Health stroke scale [NIHSS]) and disability (modified Rankin scale [mRS]). Results Serum NfL levels were elevated in both SVD samples (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2287-6391 2287-6405 |
| العلاقة: | http://www.j-stroke.org/upload/pdf/jos-2017-02565.pdfTest; https://doaj.org/toc/2287-6391Test; https://doaj.org/toc/2287-6405Test |
| DOI: | 10.5853/jos.2017.02565 |
| الوصول الحر: | https://doaj.org/article/2c81011cc81b4b8889faa77b775b111fTest |
| رقم الانضمام: | edsdoj.2c81011cc81b4b8889faa77b775b111f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22876391 22876405 |
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| DOI: | 10.5853/jos.2017.02565 |