دورية أكاديمية
The exceptions that prove the rule—a historical view of bedaquiline susceptibility
| العنوان: | The exceptions that prove the rule—a historical view of bedaquiline susceptibility |
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| المؤلفون: | Paolo Miotto, Daniela M. Cirillo, Thomas Schön, Claudio U. Köser |
| المصدر: | Genome Medicine, Vol 16, Iss 1, Pp 1-3 (2024) |
| بيانات النشر: | BMC, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Genetics |
| مصطلحات موضوعية: | Mycobacterium tuberculosis, Bedaquiline susceptibility, Resistance mutations, Clinical trials, Medicine, Genetics, QH426-470 |
| الوصف: | Abstract In the accompanying study, Nimmo and colleagues estimated the dates of emergence of mutations in mmpR5 (Rv0678), the most important resistance gene to the anti-tuberculosis drug bedaquiline, in over 3500 geographically diverse Mycobacterium tuberculosis genomes. This provided important insights to improve the design and analysis of clinical trials, as well as the World Health Organization catalogue of resistance mutations, the global reference for interpreting genotypic antimicrobial susceptibility testing results. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1756-994X |
| العلاقة: | https://doaj.org/toc/1756-994XTest |
| DOI: | 10.1186/s13073-024-01311-w |
| الوصول الحر: | https://doaj.org/article/c2c62aceee2549b69ecbee0fbdac959cTest |
| رقم الانضمام: | edsdoj.2c62aceee2549b69ecbee0fbdac959c |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 1756994X |
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| DOI: | 10.1186/s13073-024-01311-w |