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Anti-HCV antibody titer highly predicts HCV viremia in patients with hepatitis B virus dual-infection.

التفاصيل البيبلوغرافية
العنوان: Anti-HCV antibody titer highly predicts HCV viremia in patients with hepatitis B virus dual-infection.
المؤلفون: Hung-Yin Liu, Yi-Hung Lin, Pei-Ju Lin, Pei-Chien Tsai, Shu-Fen Liu, Ying-Chou Huang, Jia-Jiun Tsai, Ching-I Huang, Ming-Lun Yeh, Po-Cheng Liang, Zu-Yau Lin, Chia-Yen Dai, Jee-Fu Huang, Wan-Long Chuang, Chung-Feng Huang, Ming-Lung Yu
المصدر: PLoS ONE, Vol 16, Iss 7, p e0254028 (2021)
بيانات النشر: Public Library of Science (PLoS), 2021.
سنة النشر: 2021
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Background/aimsHepatitis C Virus (HCV) infection is diagnosed by the presence of antibody to HCV and/or HCV RNA. This study aimed to evaluate the accuracy of anti-HCV titer (S/CO ratio) in predicting HCV viremia in patients with or without hepatitis B virus (HBV) dual infection.MethodsAnti-HCV seropositive patients who were treatment-naïve consecutively enrolled. Anti-HCV antibodies were detected using a commercially chemiluminescent microparticle immunoassay. HCV RNA was detected by real-time PCR method.ResultsA total of 1321 including1196 mono-infected and 125 HBV dually infected patients were analyzed. The best cut-off value of anti-HCV titer in predicting HCV viremia was 9.95 (AUROC 0.99, PConclusionsAnti-HCV titer strongly predicted HCV viremia. This excellent performance could be generalized to either HCV mono-infected or HBV dually infected patients.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
العلاقة: https://doaj.org/toc/1932-6203Test
DOI: 10.1371/journal.pone.0254028
الوصول الحر: https://doaj.org/article/2c0a72e49af04769bdd1121140c062bfTest
رقم الانضمام: edsdoj.2c0a72e49af04769bdd1121140c062bf
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0254028