دورية أكاديمية
Therapy sculpts the complex interplay between cancer and the immune system during tumour evolution
| العنوان: | Therapy sculpts the complex interplay between cancer and the immune system during tumour evolution |
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| المؤلفون: | Kerstin Thol, Piotr Pawlik, Nicholas McGranahan |
| المصدر: | Genome Medicine, Vol 14, Iss 1, Pp 1-16 (2022) |
| بيانات النشر: | BMC, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine LCC:Genetics |
| مصطلحات موضوعية: | Tumour evolution, Immunotherapy, Immune evasion, Anti-cancer treatment, Medicine, Genetics, QH426-470 |
| الوصف: | Abstract Cancer development is an evolutionary process. A key selection pressure is exerted by therapy, one of the few players in cancer evolution that can be controlled. As such, an understanding of how treatment acts to sculpt the tumour and its microenvironment and how this influences a tumour’s subsequent evolutionary trajectory is critical. In this review, we examine cancer evolution and intra-tumour heterogeneity in the context of therapy. We focus on how radiotherapy, chemotherapy and immunotherapy shape both tumour development and the environment in which tumours evolve and how resistance can develop or be selected for during treatment. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1756-994X |
| العلاقة: | https://doaj.org/toc/1756-994XTest |
| DOI: | 10.1186/s13073-022-01138-3 |
| الوصول الحر: | https://doaj.org/article/2b0afa506c4d46b3a376ebc5cbd3d3e4Test |
| رقم الانضمام: | edsdoj.2b0afa506c4d46b3a376ebc5cbd3d3e4 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 1756994X |
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| DOI: | 10.1186/s13073-022-01138-3 |