دورية أكاديمية
The New Therapeutic Frontiers in the Treatment of Eosinophilic Esophagitis: Biological Drugs
| العنوان: | The New Therapeutic Frontiers in the Treatment of Eosinophilic Esophagitis: Biological Drugs |
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| المؤلفون: | Erminia Ridolo, Alessandro Barone, Martina Ottoni, Silvia Peveri, Marcello Montagni, Francesca Nicoletta |
| المصدر: | International Journal of Molecular Sciences, Vol 25, Iss 3, p 1702 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | biological drugs, benralizumab, cendakimab, dupilumab, eosinophilic esophagitis, lirentelimab mepolizumab, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Eosinophilic esophagitis (EoE) is a multifaceted disease characterized by a wide heterogeneity of clinical manifestations, endoscopic and histopathologic patterns, and responsiveness to therapy. From the perspective of an effective approach to the patient, the different inflammatory mechanisms involved in the pathogenesis of EoE and biologics, in particular monoclonal antibodies (mAbs), targeting these pathways are needed. Currently, the most relevant is dupilumab, which interferes with both interleukin (IL)-4 and IL-13 pathways by binding IL-4 receptor α, and is the only mAb approved by the European Medicine Agency and US Food and Drug Administration for the treatment of EoE. Other mAbs investigated include mepolizumab, reslizumab, and benralizumab (interfering with IL-5 axis), cendakimab and dectrekumab (anti-IL-13s), tezepelumab (anti-TSLP), lirentelimab (anti-SIGLEG-8), and many others. Despite the undeniable economic impact of biologic therapies, in the near future, there will be room for further reflection about the opportunity to prescribe biologic agents, not only as a last-line therapy in selected cases such as patients with comorbidities involving common pathways. Although recent findings are very encouraging, the road to permanent success in the treatment of EoE is still long, and further studies are needed to determine the long-term effects of mAbs and to discover new potential targets. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| العلاقة: | https://www.mdpi.com/1422-0067/25/3/1702Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test |
| DOI: | 10.3390/ijms25031702 |
| الوصول الحر: | https://doaj.org/article/2a4ea6bb9ed54470b0df5678d049a47cTest |
| رقم الانضمام: | edsdoj.2a4ea6bb9ed54470b0df5678d049a47c |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms25031702 |