دورية أكاديمية
Are offline ART decisions for NSCLC impacted by the type of dose calculation algorithm?
| العنوان: | Are offline ART decisions for NSCLC impacted by the type of dose calculation algorithm? |
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| المؤلفون: | Dylan Callens, Karel Aerts, Patrick Berkovic, Liesbeth Vandewinckele, Maarten Lambrecht, Wouter Crijns |
| المصدر: | Technical Innovations & Patient Support in Radiation Oncology, Vol 29, Iss , Pp 100236- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medical physics. Medical radiology. Nuclear medicine LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | NSCLC, Dose calculation, Adaptive radiotherapy, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Introduction: Decisions for plan-adaptations may be impacted by a transitioning from one dose-calculation algorithm to another. This study examines the impact on dosimetric-triggered offline adaptation in LA-NSCLC in the context of a transition from superposition/convolution dose calculation algorithm (Type-B) to linear Boltzmann equation solver dose calculation algorithms (Type-C). Materials & Methods: Two dosimetric-triggered offline adaptive treatment workflows are compared in a retrospective planning study on 30 LA-NSCLC patients. One workflow uses a Type-B dose calculation algorithm and the other uses Type-C. Treatment plans were re-calculated on the anatomy of a mid-treatment synthetic-CT utilizing the same algorithm utilized for pre-treatment planning. Assessment for plan-adaptation was evaluated through a decision model based on target coverage and OAR constraint violation. The impact of algorithm during treatment planning was controlled for by recalculating the Type-B plan with Type-C. Results: In the Type-B approach, 13 patients required adaptation due to OAR-constraint violations, while 15 patients required adaptation in the Type-C approach. For 8 out of 30 cases, the decision to adapt was opposite in both approaches. None of the patients in our dataset encountered CTV-target underdosage that necessitated plan-adaptation. Upon recalculating the Type-B approach with the Type-C algorithm, it was shown that 10 of the original Type-B plans revealed clinically relevant dose reductions (≥3%) on the CTV in their original plans. This re-calculation identified 21 plans in total that required ART. Discussion: In our study, nearly one-third of the cases would have a different decision for plan-adaption when utilizing Type-C instead of Type-B. There was no substantial increase in the total number of plan-adaptations for LA-NSCLC. However, Type-C is more sensitive to altered anatomy during treatment compared to Type-B. Recalculating Type-B plans with the Type-C algorithm revealed an increase from 13 to 21 cases triggering ART. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2405-6324 |
| العلاقة: | http://www.sciencedirect.com/science/article/pii/S2405632424000039Test; https://doaj.org/toc/2405-6324Test |
| DOI: | 10.1016/j.tipsro.2024.100236 |
| الوصول الحر: | https://doaj.org/article/c29acbd206c74211a18ef4f8f2a02d2dTest |
| رقم الانضمام: | edsdoj.29acbd206c74211a18ef4f8f2a02d2d |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24056324 |
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| DOI: | 10.1016/j.tipsro.2024.100236 |