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أعرض في EDS

TP53 Loss of Heterozygosity Induces De Novo SCLC Formation in EGFR-Mutated Lung Adenocarcinoma: A Case Report

التفاصيل البيبلوغرافية
العنوان: TP53 Loss of Heterozygosity Induces De Novo SCLC Formation in EGFR-Mutated Lung Adenocarcinoma: A Case Report
المؤلفون: Kei Kunimasa, MD, PhD, Yosuke Hirotsu, PhD, Kenji Amemiya, MSH, Harumi Nakamura, MD, PhD, Kazumi Nishino, MD, PhD, Keiichiro Honma, MD, PhD, Jiro Okami, MD, PhD, Masao Omata, MD, PhD, Toru Kumagai, MD, PhD
المصدر: JTO Clinical and Research Reports, Vol 3, Iss 5, Pp 100305- (2022)
بيانات النشر: Elsevier, 2022.
سنة النشر: 2022
المجموعة: LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
مصطلحات موضوعية: EGFR-mutated lung adenocarcinoma, Small cell lung cancer, Transformation, TP53 mutation, Loss of heterozygosity, Case report, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: SCLC transformation in EGFR-mutated lung adenocarcinoma is one of the major phenotypic changes that is observed during the resistance to EGFR tyrosine kinase inhibitors. However, the mechanism of this transformation remains unclear. In this study, we found a small de novo SCLC component in surgically resected specimens of EGFR-mutated lung adenocarcinoma before EGFR tyrosine kinase inhibitor treatment. By using laser microdissection and whole-exome sequencing, TP53 loss of heterozygosity was found to be possibly involved in SCLC transformation.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2666-3643
العلاقة: http://www.sciencedirect.com/science/article/pii/S2666364322000297Test; https://doaj.org/toc/2666-3643Test
DOI: 10.1016/j.jtocrr.2022.100305
الوصول الحر: https://doaj.org/article/28f84f778f764a779dbbe2d0cf8ba522Test
رقم الانضمام: edsdoj.28f84f778f764a779dbbe2d0cf8ba522
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:26663643
DOI:10.1016/j.jtocrr.2022.100305