دورية أكاديمية
Renal Progenitors Derived from Urine for Personalized Diagnosis of Kidney Diseases
| العنوان: | Renal Progenitors Derived from Urine for Personalized Diagnosis of Kidney Diseases |
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| المؤلفون: | Benedetta Mazzinghi, Maria Elena Melica, Laura Lasagni, Paola Romagnani, Elena Lazzeri |
| المصدر: | Kidney & Blood Pressure Research, Vol 49, Iss 1, Pp 258-265 (2024) |
| بيانات النشر: | Karger Publishers, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Dermatology LCC:Diseases of the circulatory (Cardiovascular) system LCC:Diseases of the genitourinary system. Urology |
| مصطلحات موضوعية: | renal progenitors, disease models, genetic kidney disease, acute kidney injury, chronic kidney disease, Dermatology, RL1-803, Diseases of the circulatory (Cardiovascular) system, RC666-701, Diseases of the genitourinary system. Urology, RC870-923 |
| الوصف: | Background: Chronic kidney disease affects 10% of the world population, and it is associated with progression to end-stage kidney disease and increased morbidity and mortality. The advent of multi-omics technologies has expanded our knowledge on the complexity of kidney diseases, revealing their frequent genetic etiology, particularly in children and young subjects. Genetic heterogeneity and drug screening require patient-derived disease models to establish a correct diagnosis and evaluate new potential treatments and outcomes. Summary: Patient-derived renal progenitors can be isolated from urine to set up proper disease modeling. This strategy allows to make diagnosis of genetic kidney disease in patients carrying unknown significance variants or uncover variants missed from peripheral blood analysis. Furthermore, urinary-derived tubuloids obtained from renal progenitors of patients appear to be potentially valuable for modeling kidney diseases to test ex vivo treatment efficacy or to develop new therapeutic approaches. Finally, renal progenitors derived from urine can provide insights into acute kidney injury and predict kidney function recovery and outcome. Key Messages: Renal progenitors derived from urine are a promising new noninvasive and easy-to-handle tool, which improves the rate of diagnosis and the therapeutic choice, paving the way toward a personalized healthcare. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1423-0143 |
| العلاقة: | https://beta.karger.com/Article/FullText/538507Test; https://doaj.org/toc/1423-0143Test |
| DOI: | 10.1159/000538507 |
| الوصول الحر: | https://doaj.org/article/280452f276f34d03aec72eb0e118cc5eTest |
| رقم الانضمام: | edsdoj.280452f276f34d03aec72eb0e118cc5e |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 14230143 |
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| DOI: | 10.1159/000538507 |