دورية أكاديمية
TLR4 and Insulin Resistance
| العنوان: | TLR4 and Insulin Resistance |
|---|---|
| المؤلفون: | Jane J. Kim, Dorothy D. Sears |
| المصدر: | Gastroenterology Research and Practice, Vol 2010 (2010) |
| بيانات النشر: | Hindawi Limited, 2010. |
| سنة النشر: | 2010 |
| المجموعة: | LCC:Diseases of the digestive system. Gastroenterology |
| مصطلحات موضوعية: | Diseases of the digestive system. Gastroenterology, RC799-869 |
| الوصف: | Chronic inflammation is a key feature of insulin resistance and obesity. Toll-Like Receptor 4 (TLR4), involved in modulating innate immunity, is an important mediator of insulin resistance and its comorbidities. TLR4 contributes to the development of insulin resistance and inflammation through its activation by elevated exogenous ligands (e.g., dietary fatty acids and enteric lipopolysaccharide) and endogenous ligands (e.g., free fatty acids) which are elevated in obese states. TLR4, expressed in insulin target tissues, activates proinflammatory kinases JNK, IKK, and p38 that impair insulin signal transduction directly through inhibitory phosphorylation of insulin receptor substrate (IRS) on serine residues. TLR4 activation also leads to increased transcription of pro-inflammatory genes, resulting in elevation of cytokine, chemokine, reactive oxygen species, and eicosanoid levels that promote further insulin-desensitization within the target cell itself and in other cells via paracrine and systemic effects. Increased understanding of cell type-specific TLR4-mediated effects on insulin action present the opportunity and challenge of developing related therapeutic approaches for improving insulin sensitivity while preserving innate immunity. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1687-6121 1687-630X |
| العلاقة: | https://doaj.org/toc/1687-6121Test; https://doaj.org/toc/1687-630XTest |
| DOI: | 10.1155/2010/212563 |
| الوصول الحر: | https://doaj.org/article/279448d4faae43e88f7e2c331989ecf7Test |
| رقم الانضمام: | edsdoj.279448d4faae43e88f7e2c331989ecf7 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16876121 1687630X |
|---|---|
| DOI: | 10.1155/2010/212563 |