دورية أكاديمية
Vitamin K Dependent Protection of Renal Function in Multi-ethnic Population Studies
| العنوان: | Vitamin K Dependent Protection of Renal Function in Multi-ethnic Population Studies |
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| المؤلفون: | Fang-Fei Wei, Nadja E.A. Drummen, Aletta E. Schutte, Lutgarde Thijs, Lotte Jacobs, Thibaut Petit, Wen-Yi Yang, Wayne Smith, Zhen-Yu Zhang, Yu-Mei Gu, Tatiana Kuznetsova, Peter Verhamme, Karel Allegaert, Rudolph Schutte, Evelyne Lerut, Pieter Evenepoel, Cees Vermeer, Jan A. Staessen |
| المصدر: | EBioMedicine, Vol 4, Iss C, Pp 162-169 (2016) |
| بيانات النشر: | Elsevier, 2016. |
| سنة النشر: | 2016 |
| المجموعة: | LCC:Medicine LCC:Medicine (General) |
| مصطلحات موضوعية: | Chronic kidney disease, Glomerular filtration rate, Matrix Gla protein, Population science, Vitamin K, Medicine, Medicine (General), R5-920 |
| الوصف: | Background: Following activation by vitamin K (VK), matrix Gla protein (MGP) inhibits arterial calcification, but its role in preserving renal function remains unknown. Methods: In 1166 white Flemish (mean age, 38.2 years) and 714 South Africans (49.2% black; 40.6 years), we correlated estimated glomerular filtration (eGFR [CKD-EPI formula]) and stage of chronic kidney disease (CKD [KDOQI stages 2–3]) with inactive desphospho-uncarboxylated MGP (dp-ucMGP), using multivariable linear and logistic regression. Results: Among Flemish and white and black Africans, between-group differences in eGFR (90, 100 and 122 mL/min/1.73 m2), dp-ucMGP (3.7, 6.5 and 3.2 μg/L), and CKD prevalence (53.5, 28.7 and 10.5%) were significant, but associations of eGFR with dp-ucMGP did not differ among ethnicities (P ≥ 0.075). For a doubling of dp-ucMGP, eGFR decreased by 1.5 (P = 0.023), 1.0 (P = 0.56), 2.8 (P = 0.0012) and 2.1 (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2352-3964 |
| العلاقة: | http://www.sciencedirect.com/science/article/pii/S2352396416300093Test; https://doaj.org/toc/2352-3964Test |
| DOI: | 10.1016/j.ebiom.2016.01.011 |
| الوصول الحر: | https://doaj.org/article/2772294ebf90432c8500d81348a09f61Test |
| رقم الانضمام: | edsdoj.2772294ebf90432c8500d81348a09f61 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23523964 |
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| DOI: | 10.1016/j.ebiom.2016.01.011 |