دورية أكاديمية
Cold Storage, HepG2, Platelet Transfusion, Trehalose
| العنوان: | Cold Storage, HepG2, Platelet Transfusion, Trehalose |
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| المؤلفون: | Sahar Samieyan Dehkordi, Seyed Hadi Mousavi, Marzieh Ebrahimi, Shaban Alizadeh, Amir Abbas Hedayati Asl, Monireh Mohammad, Bahareh Aliabedi |
| المصدر: | Cell Journal, Pp 76-84 (2022) |
| بيانات النشر: | Royan Institute (ACECR), Tehran, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | acute myeloid leukemia, cox2, integrin-linked kinase, invasion, mmp9, Medicine, Science |
| الوصف: | Objective: Acute myeloid leukemia (AML) is characterized by abnormalities of differentiation and growth of primary hematopoietic stem cells (HSCs) in the blood and bone marrow. In many studies, miR-625-5p has been shown to inhibit downstream pathways from affecting the metastasis and invasion of the integrin-linked kinase (ILK) signaling pathway. It has been proved that the expression of miR-625-5p decreases in AML cell lines. This study aimed to investigate the effect of miR-625-5p upregulation on the invasion of KG1 ell line in vitro. Materials and Methods: In this experimental study, we investigated the impact of upregulation of miR-625-5p on invasion via the ILK/AKT pathway in the KG1 cell line. After transfection using the viral method, the cellular invasion was assessed by invasion assay and the levels of miR-625-5p genes and protein were evaluated by quantitative polymerase chain reaction (qPCR) and western blotting. Moreover, CXCR4 level was assessed by flow cytometry. Results: The invasion significantly reduced in MiR-625-5p-transfected KG1 cells (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2228-5806 2228-5814 |
| العلاقة: | https://celljournal.org/journal/article/fulltext/upregulation-of-hsa-mir-625-5p-inhibits-invasion-of-acute-myeloid-leukemia-cancer-cells-through-ilkakt-pathway.pdfTest; https://doaj.org/toc/2228-5806Test; https://doaj.org/toc/2228-5814Test |
| DOI: | 10.22074/cellj.2022.7658 |
| الوصول الحر: | https://doaj.org/article/26d4b12f3f934793b5edaf87375c144bTest |
| رقم الانضمام: | edsdoj.26d4b12f3f934793b5edaf87375c144b |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22285806 22285814 |
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| DOI: | 10.22074/cellj.2022.7658 |