دورية أكاديمية
Evaluation of MMP-9, IL-6, TNF-α levels and peripheral blood mononuclear cells genes expression of MMP-9 and TIMP-1 in Iranian patients with coronary artery disease
| العنوان: | Evaluation of MMP-9, IL-6, TNF-α levels and peripheral blood mononuclear cells genes expression of MMP-9 and TIMP-1 in Iranian patients with coronary artery disease |
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| المؤلفون: | Tooran Akbari, Toktam Kazemi Fard, Reza Fadaei, Rahim Rostami, Nariman Moradi, Monireh Movahedi, Soudabeh Fallah |
| المصدر: | Journal of Cardiovascular and Thoracic Research, Vol 15, Iss 4, Pp 223-230 (2023) |
| بيانات النشر: | Tabriz University of Medical Sciences, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Diseases of the circulatory (Cardiovascular) system |
| مصطلحات موضوعية: | coronary artery disease (cad), cytokines, inflammation, matrix metallopeptidase 9 (mmp-9), tissue inhibitor of metalloproteinase (timp-1), Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| الوصف: | Introduction: Coronary artery disease (CAD) is the main cause of death and is characterized by atherosclerosis in coronary arteries. Inflammation plays a crucial role in the progression and development of atherosclerosis. Methods: The present study consisted of 132 Iranian individuals who underwent coronary angiography, 65 patients with CAD, and 67 controls. The matrix metalloproteinase-9 (MMP-9), TNF-α, IL-6, and vitamin D serum levels were measured by the ELISA technique. The gene expression of MMP-9 and tissue inhibitors of metalloproteinase (TIMP-1) was estimated by real-time PCR assay. Results: A considerable increase in levels and PBMC gene expression of MMP-9 and serum levels of IL-6 and TNF-α were found in CAD patients compared with controls. A significant decrease was detected in vitamin D levels of CAD patients in comparison with controls. A considerable direct correlation was found between MMP-9 levels and MMP-9 and TIMP1 gene expression in CAD patients. MMP-9 levels positively correlated with LDL-C in CAD patients. The correlation between TIMP1 gene expression and IL-6 levels was also negatively significant. There were positive correlations between MMP-9 levels with IL-6 and TNF-α serum levels in CAD patients. Conclusion: This study showed that the interaction between MMPs, TIMP1, and cytokines could play a role in the pathogenesis of atherosclerosis. The present study suggested that high levels of TNF-α and IL-6 and vitamin D deficiency in our studied patients could disturb the MMP-9/TIMP-1 balance and lipid metabolism, leading to plaque formation/ rupture in predisposed CAD patients. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2008-5117 2008-6830 |
| العلاقة: | https://jcvtr.tbzmed.ac.ir/PDF/jcvtr-15-223.pdfTest; https://doaj.org/toc/2008-5117Test; https://doaj.org/toc/2008-6830Test |
| DOI: | 10.34172/jcvtr.2023.31844 |
| الوصول الحر: | https://doaj.org/article/249117eaaeeb4e18befd7e690a081a68Test |
| رقم الانضمام: | edsdoj.249117eaaeeb4e18befd7e690a081a68 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20085117 20086830 |
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| DOI: | 10.34172/jcvtr.2023.31844 |