دورية أكاديمية
Optimizing the biodegradability and osteogenesis of biogenic collagen membrane via fluoride-modified polymer-induced liquid precursor process
| العنوان: | Optimizing the biodegradability and osteogenesis of biogenic collagen membrane via fluoride-modified polymer-induced liquid precursor process |
|---|---|
| المؤلفون: | Xiyan Li, Chuangji Li, Mengxi Su, Xinyi Zhong, Yihan Xing, Zhengjie Shan, Shoucheng Chen, Xingchen Liu, Xiayi Wu, Quan Liu, Ye Li, Shiyu Wu, Zhuofan Chen |
| المصدر: | Science and Technology of Advanced Materials, Vol 24, Iss 1 (2023) |
| بيانات النشر: | Taylor & Francis Group, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Materials of engineering and construction. Mechanics of materials LCC:Biotechnology |
| مصطلحات موضوعية: | Collagen membrane, degradation, amorphous calcium phosphate, polymer-induced liquid precursor, fluoride, Materials of engineering and construction. Mechanics of materials, TA401-492, Biotechnology, TP248.13-248.65 |
| الوصف: | ABSTRACTBiogenic collagen membranes (BCM) have been widely used in guided bone regeneration (GBR) owing to their biodegradability during tissue integration. However, their relatively high degradation rate and lack of pro-osteogenic properties limit their clinical outcomes. It is of great importance to endow BCM with tailored degradation as well as pro-osteogenic properties. In this study, a fluoride-modified polymer-induced liquid precursor (PILP) based biomineralization strategy was used to convert the collagen membrane from an organic phase to an apatite-based inorganic phase, thus achieving enhanced anti-degradation performance as well as osteogenesis. As a result, three phases of collagen membranes were prepared. The original BCM in the organic phase induced the mildest inflammatory response and was mostly degraded after 4 weeks. The organic-inorganic mixture phase of the collagen membrane evoked a prominent inflammatory response owing to the fluoride-containing amorphous calcium phosphate (F-ACP) nanoparticles, resulting in active angiogenesis and fibrous encapsulation, whereas the inorganic phase induced a mild inflammatory response and degraded the least owing to the transition of F-ACP particles into calcium phosphate with high crystallinity. Effective control of ACP is key to building novel apatite-based barrier membranes. The current results may pave the way for the development of advanced apatite-based membranes with enhanced barrier performances. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 14686996 1878-5514 1468-6996 |
| العلاقة: | https://doaj.org/toc/1468-6996Test; https://doaj.org/toc/1878-5514Test |
| DOI: | 10.1080/14686996.2023.2186690 |
| الوصول الحر: | https://doaj.org/article/246af73b66284e52b8120c200dfaa543Test |
| رقم الانضمام: | edsdoj.246af73b66284e52b8120c200dfaa543 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14686996 18785514 |
|---|---|
| DOI: | 10.1080/14686996.2023.2186690 |