دورية أكاديمية
A preliminary study of the genes related to aggression and insensitivity to pain in autism spectrum disorders
| العنوان: | A preliminary study of the genes related to aggression and insensitivity to pain in autism spectrum disorders |
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| المؤلفون: | Elif Funda Sener, Mustafa Caglar Sahin, Serpil Taheri, Keziban Korkmaz Bayramov, Mert Kahraman Marasli, Gokmen Zararsiz, Mehmet Canpolat, Nilfer Sahin, Didem Behice Oztop |
| المصدر: | Psychiatry and Clinical Psychopharmacology, Vol 27, Iss 1, Pp 24-29 (2017) |
| بيانات النشر: | AVES, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| مصطلحات موضوعية: | Autism spectrum disorders, aggression, insensitivity to pain, expression, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| الوصف: | Objective: Autism spectrum disorders (ASDs) is a heterogeneous neuropsychiatric disorder with widespread abnormalities of social interaction and communication, showing severely restricted interests and extreme repetitive behavior. The relationship between aggressive behavior, insensitivity to pain, and ASDs could not be explained completely. Therefore, we aimed to contribute to the etiology by examining the gene expressions of OPRL1, TACR1, and HTR1E in patients with ASDs. Methods: This study was held in the Genome and Stem Cell Research Center of Erciyes University. In this present study, the expressions of OPRL1, TACR1, and HTR1E genes were studied in 22 ASD patients and 14 healthy controls. Quantitative Real-time Polymerase Chain Reaction (qRT-PCR) was used for gene expression studies. Results: There was a statistically significant difference in terms of the expression of the three genes, which we examined between the ASD patient and control groups. Positive and strong correlations were obtained between the three gene expressions in the ASD group and this finding was found to be statistically significant. Conclusions: Considering all these findings, large-scale and new researches are needed for revealing the roles of genes and their pathways which are related to aggression and insensitivity to pain in ASDs. Our results will lead to new research studies in this field. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2475-0573 2475-0581 24750573 |
| العلاقة: | https://doaj.org/toc/2475-0573Test; https://doaj.org/toc/2475-0581Test |
| DOI: | 10.1080/24750573.2017.1293248 |
| الوصول الحر: | https://doaj.org/article/ac1f75ba080448f087e613ecb5b921e8Test |
| رقم الانضمام: | edsdoj.1f75ba080448f087e613ecb5b921e8 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 24750573 24750581 |
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| DOI: | 10.1080/24750573.2017.1293248 |