دورية أكاديمية
Multivariate analysis of clinicopathological and prognostic significance of miRNA 106b~25 cluster in gastric cancer
| العنوان: | Multivariate analysis of clinicopathological and prognostic significance of miRNA 106b~25 cluster in gastric cancer |
|---|---|
| المؤلفون: | Fangxuan Li, Jinchao Huang, Juntian Liu, Wengui Xu, Zhiyong Yuan |
| المصدر: | Cancer Cell International, Vol 19, Iss 1, Pp 1-10 (2019) |
| بيانات النشر: | BMC, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens LCC:Cytology |
| مصطلحات موضوعية: | miRNA 106b, miRNA 93, miRNA 25, Gastric cancer, PCA, PLS-DA, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671 |
| الوصف: | Abstract Background miRNA 106b~25 cluster were demonstrated to be an oncogene. In previous study, we had analyzed the diagnostic significance of miRNA 106b~25 based on its carcinogenesis effect. The significance of miRNA 106b~25 for prognosis of gastric cancer were not researched. Methods We applied multivariate analysis of PCA, PLS-DA and Cox Regression for clinicopathological features and survival time to explore the significance of miRNA 106b~25 expression in plasma and cancer tissues for gastric cancer. Results The expression of miRNA 106b, miRNA 93 and miRNA 25 in plasma were positively correlated with their expression in tumor tissues. Via PCA analysis, it was found that miRNA 106b~25 expression in plasma and tumor, T, N and TNM stage were correlated with each other. Via PLS-DA analysis, we identified that T, N and TNM stage were important factors for miRNA 106b~25 expression both in plasma and tumor (all VIP value > 1.2). According to loading weights of variables for the first and second components, it was found that the importance of the miRNA 106b~25s expression carried with the progressed stage of gastric cancer. In the survival analysis, COX regression showed that T stage, plasma miRNA 106b and tumor miRNA 93 were significant risk factors for overall survival [HR: 0.400 (0.205–0.780); P = 0.007; HR: 0.371 (0.142–0.969), P = 0.043; 0.295 (0.134–0.650), P = 0.002]. Conclusion Plasma and tumor miRNA 106b~25 expression correlated with T, N and TNM stage. Increased miRNA 106b~25 expression was important characters carried with gastric cancer progression. T stage, plasma miRNA106b and tumor miRNA 93 significant risk factors for overall survival. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1475-2867 |
| العلاقة: | http://link.springer.com/article/10.1186/s12935-019-0918-7Test; https://doaj.org/toc/1475-2867Test |
| DOI: | 10.1186/s12935-019-0918-7 |
| الوصول الحر: | https://doaj.org/article/1e327b5cc87d4da2b30b66942a3fc7c7Test |
| رقم الانضمام: | edsdoj.1e327b5cc87d4da2b30b66942a3fc7c7 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14752867 |
|---|---|
| DOI: | 10.1186/s12935-019-0918-7 |