دورية أكاديمية
The Current and Emerging Role of Statins in the Treatment of PCOS: The Evidence to Date
| العنوان: | The Current and Emerging Role of Statins in the Treatment of PCOS: The Evidence to Date |
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| المؤلفون: | Tea Shehu Kolnikaj, Rok Herman, Andrej Janež, Mojca Jensterle |
| المصدر: | Medicina, Vol 60, Iss 2, p 244 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine (General) |
| مصطلحات موضوعية: | polycystic ovary syndrome, steroidogenesis, hyperandrogenemia, statins, dyslipidemia, Medicine (General), R5-920 |
| الوصف: | Polycystic ovary syndrome (PCOS) manifests a multifactorial pathology characterized by polycystic ovaries, menstrual cycle disorders, varying degrees of hyperandrogenism, and an ad-verse metabolic risk profile. The position of hyperandrogenism in this syndrome has been extensively studied. A multitude of mechanisms place it in the position of cause but also of consequence; therefore, ongoing research efforts are focused on identifying medications that can effectively reduce levels of androgens in women with PCOS. Moreover, lipid abnormalities are common in this population, with up to 70% of patients having dyslipidemia. Statins may have potential therapeutic benefits for women with PCOS, as they have been shown to improve insulin resistance and reduce the risk of cardiovascular disease. In addition, their role in accelerated steroidogenesis by limiting one source of cholesterol, influencing enzymatic activity, and providing several other beneficial mechanisms is widely investigated. This review aimed to provide a comprehensive overview of the pathogenesis of androgen excess and dyslipidemia in PCOS, as well as the therapeutic potential of statins. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1648-9144 1010-660X |
| العلاقة: | https://www.mdpi.com/1648-9144/60/2/244Test; https://doaj.org/toc/1010-660XTest; https://doaj.org/toc/1648-9144Test |
| DOI: | 10.3390/medicina60020244 |
| الوصول الحر: | https://doaj.org/article/1cb7fdbe379449c696bcb9744b34c77eTest |
| رقم الانضمام: | edsdoj.1cb7fdbe379449c696bcb9744b34c77e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16489144 1010660X |
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| DOI: | 10.3390/medicina60020244 |