دورية أكاديمية
Renal effects and safety between Asian and non‐Asian chronic kidney disease and type 2 diabetes treated with nonsteroidal mineralocorticoid antagonists
| العنوان: | Renal effects and safety between Asian and non‐Asian chronic kidney disease and type 2 diabetes treated with nonsteroidal mineralocorticoid antagonists |
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| المؤلفون: | Xiaoming Xu, Jing Feng, Yuying Cui, Pingjiang Li, Jianjun Dong, Lin Liao |
| المصدر: | Journal of Diabetes, Vol 16, Iss 6, Pp n/a-n/a (2024) |
| بيانات النشر: | Wiley, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Diseases of the endocrine glands. Clinical endocrinology |
| مصطلحات موضوعية: | Asians, chronic kidney disease, non‐Asians, nonsteroidal mineralocorticoid receptor antagonists, type 2 diabetes mellitus, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| الوصف: | Abstract Background Asians bear a heavier burden of chronic kidney disease (CKD), a common comorbidity of type 2 diabetes mellitus (T2DM), than non‐Asians. Nonsteroidal mineralocorticoid receptor antagonists (MRAs) have garnered attention for their potential advantages in renal outcomes. Nevertheless, the impact on diverse ethnic groups remains unknown. Methods The PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang database, and clinical trial registries were searched through August 2023 with the following keywords: nonsteroidal MRAs (finerenone, apararenone, esaxerenone, AZD9977, KBP‐5074), CKD, T2DM, and randomized controlled trial (RCT). A random effects model was used to calculate overall effect sizes. Results Seven RCTs with 14 997 participants were enrolled. Nonsteroidal MRAs reduced urinary albumin to creatinine ratio (UACR) significantly more in Asians than non‐Asians: (weighted mean difference [WMD], −0.59, 95% CI, −0.73 to −0.45, p .05). Regarding systolic blood pressure (SBP), nonsteroidal MRAs had a better antihypertension performance in Asians (WMD, −5.12, 95% CI, −5.84 to −4.41, p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1753-0407 1753-0393 |
| العلاقة: | https://doaj.org/toc/1753-0393Test; https://doaj.org/toc/1753-0407Test |
| DOI: | 10.1111/1753-0407.13566 |
| الوصول الحر: | https://doaj.org/article/1b4d0236bf294e02bfa6bae441884c61Test |
| رقم الانضمام: | edsdoj.1b4d0236bf294e02bfa6bae441884c61 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17530407 17530393 |
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| DOI: | 10.1111/1753-0407.13566 |