التفاصيل البيبلوغرافية
العنوان:
A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine
المؤلفون:
Carlos Sebastian , Christina Ferrer , Maria Serra , Jee-Eun Choi , Nadia Ducano , Alessia Mira , Manasvi S. Shah , Sylwia A. Stopka , Andrew J. Perciaccante , Claudio Isella , Daniel Moya-Rull , Marianela Vara-Messler , Silvia Giordano , Elena Maldi , Niyati Desai , Diane E. Capen , Enzo Medico , Murat Cetinbas , Ruslan I. Sadreyev , Dennis Brown , Miguel N. Rivera , Anna Sapino , David T. Breault , Nathalie Y. R. Agar , Raul Mostoslavsky
المصدر:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
بيانات النشر:
Nature Portfolio, 2022.
سنة النشر:
2022
المجموعة:
LCC:Science
مصطلحات موضوعية:
Science
الوصف:
Metabolic reprogramming upon SIRT6 loss induces tumour formation in the intestine but the mechanism is unclear. Here, the authors show that loss of SIRT6 leads to the expansion of epithelial cells with high pyruvate dehydrogenase kinase activity resulting in enhanced stem cell activity and tumour-initiating potential
نوع الوثيقة:
article
وصف الملف:
electronic resource
اللغة:
English
تدمد:
2041-1723
العلاقة:
https://doaj.org/toc/2041-1723Test
DOI:
10.1038/s41467-022-29085-y
الوصول الحر:
https://doaj.org/article/1ae650e5a5c942e78cc7775f36dd9685Test
رقم الانضمام:
edsdoj.1ae650e5a5c942e78cc7775f36dd9685
قاعدة البيانات:
Directory of Open Access Journals
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