دورية أكاديمية
Brief communication: global temporal trends in the efficacy of clarithromycin-based regimens for the treatment of infection
| العنوان: | Brief communication: global temporal trends in the efficacy of clarithromycin-based regimens for the treatment of infection |
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| المؤلفون: | Steven F. Moss, William D. Chey, Patrick Daniele, Corey Pelletier, Rinu Jacob, Gabriel Tremblay, Elizabeth Hubscher, Eckhard Leifke, Peter Malfertheiner |
| المصدر: | Therapeutic Advances in Gastroenterology, Vol 16 (2023) |
| بيانات النشر: | SAGE Publishing, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Diseases of the digestive system. Gastroenterology |
| مصطلحات موضوعية: | Diseases of the digestive system. Gastroenterology, RC799-869 |
| الوصف: | Background: Helicobacter pylori eradication rates achieved with clarithromycin-based triple therapies are declining due to antibiotic resistance, but data regarding temporal changes in efficacy with these eradication therapies are scarce. Objective: To evaluate the efficacy of clarithromycin-based triple eradication regimens over time. Design: A comprehensive literature review and time-trend analysis. Data sources and methods: Bibliographies of recently published systematic literature reviews were searched and supplemented with a targeted literature review conducted using Medline and Embase databases and ProQuest from conception to May 2021. Studies reporting H. pylori eradication rates of clarithromycin-based triple therapies were included and temporal trends were estimated using a random-effects model. Results: Eradication rates for triple therapies containing proton pump inhibitors (PPIs), clarithromycin, and amoxicillin showed a significant decline over the past 23 years ( p = 0.0315). However, this decline was not significant when eradication rates achieved with vonoprazan-based triple therapy were included ( p = 0.3910). Conclusion: Vonoprazan-based triple therapy partially mitigated the decline in eradication rates seen with PPI-based triple therapy, likely due to more powerful acid suppression of vonoprazan. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1756-2848 17562848 |
| العلاقة: | https://doaj.org/toc/1756-2848Test |
| DOI: | 10.1177/17562848231167284 |
| الوصول الحر: | https://doaj.org/article/ac1976321b6341f2b3feab136665bb2bTest |
| رقم الانضمام: | edsdoj.1976321b6341f2b3feab136665bb2b |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17562848 |
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| DOI: | 10.1177/17562848231167284 |