دورية أكاديمية
HTLV-1 tax specific CD8+ T cells express low levels of Tim-3 in HTLV-1 infection: implications for progression to neurological complications.
| العنوان: | HTLV-1 tax specific CD8+ T cells express low levels of Tim-3 in HTLV-1 infection: implications for progression to neurological complications. |
|---|---|
| المؤلفون: | Lishomwa C Ndhlovu, Fabio E Leal, Aaron M Hasenkrug, Aashish R Jha, Karina I Carvalho, Ijeoma G Eccles-James, Fernanda R Bruno, Raphaella G S Vieira, Vanessa A York, Glen M Chew, R Brad Jones, Yuetsu Tanaka, Walter K Neto, Sabri S Sanabani, Mario A Ostrowski, Aluisio C Segurado, Douglas F Nixon, Esper G Kallas |
| المصدر: | PLoS Neglected Tropical Diseases, Vol 5, Iss 4, p e1030 (2011) |
| بيانات النشر: | Public Library of Science (PLoS), 2011. |
| سنة النشر: | 2011 |
| المجموعة: | LCC:Arctic medicine. Tropical medicine LCC:Public aspects of medicine |
| مصطلحات موضوعية: | Arctic medicine. Tropical medicine, RC955-962, Public aspects of medicine, RA1-1270 |
| الوصف: | The T cell immunoglobulin mucin 3 (Tim-3) receptor is highly expressed on HIV-1-specific T cells, rendering them partially "exhausted" and unable to contribute to the effective immune mediated control of viral replication. To elucidate novel mechanisms contributing to the HTLV-1 neurological complex and its classic neurological presentation called HAM/TSP (HTLV-1 associated myelopathy/tropical spastic paraparesis), we investigated the expression of the Tim-3 receptor on CD8(+) T cells from a cohort of HTLV-1 seropositive asymptomatic and symptomatic patients. Patients diagnosed with HAM/TSP down-regulated Tim-3 expression on both CD8(+) and CD4(+) T cells compared to asymptomatic patients and HTLV-1 seronegative controls. HTLV-1 Tax-specific, HLA-A*02 restricted CD8(+) T cells among HAM/TSP individuals expressed markedly lower levels of Tim-3. We observed Tax expressing cells in both Tim-3(+) and Tim-3(-) fractions. Taken together, these data indicate that there is a systematic downregulation of Tim-3 levels on T cells in HTLV-1 infection, sustaining a profoundly highly active population of potentially pathogenic T cells that may allow for the development of HTLV-1 complications. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1935-2727 1935-2735 |
| العلاقة: | http://europepmc.org/articles/PMC3082508?pdf=renderTest; https://doaj.org/toc/1935-2727Test; https://doaj.org/toc/1935-2735Test |
| DOI: | 10.1371/journal.pntd.0001030 |
| الوصول الحر: | https://doaj.org/article/190061c58fcc422885cc5232b6d96652Test |
| رقم الانضمام: | edsdoj.190061c58fcc422885cc5232b6d96652 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19352727 19352735 |
|---|---|
| DOI: | 10.1371/journal.pntd.0001030 |