التفاصيل البيبلوغرافية
العنوان:
SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4
المؤلفون:
Konstantinos Tzelepis , Etienne De Braekeleer , Demetrios Aspris , Isaia Barbieri , M. S. Vijayabaskar , Wen-Hsin Liu , Malgorzata Gozdecka , Emmanouil Metzakopian , Hamish D. Toop , Monika Dudek , Samuel C. Robson , Francisco Hermida-Prado , Yu Hsuen Yang , Roya Babaei-Jadidi , Dimitrios A. Garyfallos , Hannes Ponstingl , Joao M. L. Dias , Paolo Gallipoli , Michael Seiler , Silvia Buonamici , Binje Vick , Andrew J. Bannister , Roland Rad , Rab K. Prinjha , John C. Marioni , Brian Huntly , Jennifer Batson , Jonathan C. Morris , Cristina Pina , Allan Bradley , Irmela Jeremias , David O. Bates , Kosuke Yusa , Tony Kouzarides , George S. Vassiliou
المصدر:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
بيانات النشر:
Nature Portfolio, 2018.
سنة النشر:
2018
المجموعة:
LCC:Science
مصطلحات موضوعية:
Science
الوصف:
SRPK1, a kinase involved in splicing regulation, is a potential therapeutic target for AML patients. Here, the authors show that SRPK1 inhibition changes isoform levels of key epigenetic regulators, including BRD4, and it has anti-tumor effects specifically against MLL-rearranged AML cells.
نوع الوثيقة:
article
وصف الملف:
electronic resource
اللغة:
English
تدمد:
2041-1723
العلاقة:
https://doaj.org/toc/2041-1723Test
DOI:
10.1038/s41467-018-07620-0
الوصول الحر:
https://doaj.org/article/1853a1ced0ff46dfaf75bec9896c8581Test
رقم الانضمام:
edsdoj.1853a1ced0ff46dfaf75bec9896c8581
قاعدة البيانات:
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