دورية أكاديمية
Oxyntomodulin Identified as a Marker of Type 2 Diabetes and Gastric Bypass Surgery by Mass-spectrometry Based Profiling of Human Plasma
| العنوان: | Oxyntomodulin Identified as a Marker of Type 2 Diabetes and Gastric Bypass Surgery by Mass-spectrometry Based Profiling of Human Plasma |
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| المؤلفون: | Nicolai J. Wewer Albrechtsen, Daniel Hornburg, Reidar Albrechtsen, Berit Svendsen, Signe Toräng, Sara L. Jepsen, Rune E. Kuhre, Marie Hansen, Charlotte Janus, Andrea Floyd, Asger Lund, Tina Vilsbøll, Filip K. Knop, Henrik Vestergaard, Carolyn F. Deacon, Felix Meissner, Matthias Mann, Jens J. Holst, Bolette Hartmann |
| المصدر: | EBioMedicine, Vol 7, Iss C, Pp 112-120 (2016) |
| بيانات النشر: | Elsevier, 2016. |
| سنة النشر: | 2016 |
| المجموعة: | LCC:Medicine LCC:Medicine (General) |
| مصطلحات موضوعية: | Gut hormones, GLP-1, Low-abundant peptides, Mass-spectrometry, Proteomics, Medicine, Medicine (General), R5-920 |
| الوصف: | Low-abundance regulatory peptides, including metabolically important gut hormones, have shown promising therapeutic potential. Here, we present a streamlined mass spectrometry-based platform for identifying and characterizing low-abundance regulatory peptides in humans. We demonstrate the clinical applicability of this platform by studying a hitherto neglected glucose- and appetite-regulating gut hormone, namely, oxyntomodulin. Our results show that the secretion of oxyntomodulin in patients with type 2 diabetes is significantly impaired, and that its level is increased by more than 10-fold after gastric bypass surgery. Furthermore, we report that oxyntomodulin is co-distributed and co-secreted with the insulin-stimulating and appetite-regulating gut hormone glucagon-like peptide-1 (GLP-1), is inactivated by the same protease (dipeptidyl peptidase-4) as GLP-1 and acts through its receptor. Thus, oxyntomodulin may participate with GLP-1 in the regulation of glucose metabolism and appetite in humans. In conclusion, this mass spectrometry-based platform is a powerful resource for identifying and characterizing metabolically active low-abundance peptides. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2352-3964 |
| العلاقة: | http://www.sciencedirect.com/science/article/pii/S2352396416301220Test; https://doaj.org/toc/2352-3964Test |
| DOI: | 10.1016/j.ebiom.2016.03.034 |
| الوصول الحر: | https://doaj.org/article/18223ff3e5574a79a867add2c09dfbaeTest |
| رقم الانضمام: | edsdoj.18223ff3e5574a79a867add2c09dfbae |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23523964 |
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| DOI: | 10.1016/j.ebiom.2016.03.034 |