دورية أكاديمية
Survey of Anaphylaxis during Rasburicase Re-Administration in Patients with Hematological Malignancies Using a Japanese Claims Database
| العنوان: | Survey of Anaphylaxis during Rasburicase Re-Administration in Patients with Hematological Malignancies Using a Japanese Claims Database |
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| المؤلفون: | Shunsuke Kobayashi, Takeo Yasu, Manabu Akazawa |
| المصدر: | Current Oncology, Vol 29, Iss 12, Pp 9826-9832 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | rasburicase, anaphylaxis, re-administration, hematological malignancies, claims data, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Management of tumor lysis syndrome (TLS) associated with cancer chemotherapy for malignant tumors is important because of its potentially fatal course. The use of rasburicase, a recombinant urate oxidase, is recommended for TLS; however, because rasburicase is an enzymatic drug, one should be cautious of anaphylaxis during administration. Using claims data in Japan, we investigated the rate of rasburicase re-administration and the occurrence of anaphylaxis during re-administration in patients with hematopoietic malignancies in a multicenter setting. Re-administration of rasburicase was defined as administration after an interval of 21 days from the first dose. Of 373 patients, 18 were re-administered rasburicase (re-administration rate: 4.8%). No patient developed anaphylaxis. The median number of days from the first to the last dose of rasburicase was 256.5 days (interquartile range: 138.8–455.8 days). The median daily dose was 7.5 mg (4.5–11.3 mg), and the median total dose was 33.8 mg (19.1–64.1 mg). This claims database analysis revealed that the re-administration rate of rasburicase was low in Japanese patients with hematopoietic malignancies, suggesting that rasburicase was being used appropriately, and that associated anaphylaxis was not observed. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 29120772 1718-7729 1198-0052 |
| العلاقة: | https://www.mdpi.com/1718-7729/29/12/772Test; https://doaj.org/toc/1198-0052Test; https://doaj.org/toc/1718-7729Test |
| DOI: | 10.3390/curroncol29120772 |
| الوصول الحر: | https://doaj.org/article/e1805caff25f48b5a0235a591d0ae0b5Test |
| رقم الانضمام: | edsdoj.1805caff25f48b5a0235a591d0ae0b5 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 29120772 17187729 11980052 |
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| DOI: | 10.3390/curroncol29120772 |