دورية أكاديمية
CD44-targeted pH-responsive micelles for enhanced cellular internalization and intracellular on-demand release of doxorubicin
العنوان: | CD44-targeted pH-responsive micelles for enhanced cellular internalization and intracellular on-demand release of doxorubicin |
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المؤلفون: | Shudi Yang, Weiliang Chen, Wei Li, Jingcheng Song, Yue Gao, Xiaoping Li |
المصدر: | Artificial Cells, Nanomedicine, and Biotechnology, Vol 49, Iss 1, Pp 173-184 (2021) |
بيانات النشر: | Taylor & Francis Group, 2021. |
سنة النشر: | 2021 |
المجموعة: | LCC:Biotechnology LCC:Medical technology |
مصطلحات موضوعية: | CD44 targeted, pH responsive, micelles, doxorubicin, on-demand release, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5 |
الوصف: | Poor cellular uptake and slow intracellular drug release remain the main barriers for the efficient application of micellar delivery system. Taking advantage of the overexpressed CD44 receptor and mild acidic microenvironment of tumour cells, CD44-targeted pH-responsive micelles based on the self-assembly of histidine–hyaluronic acid–dodecylamine (His–HA–DA) were prepared for the delivery of doxorubicin (DOX). These micelles exhibited pH-responsive behaviour with increased particle size, decreased encapsulation efficiency (EE%) of DOX and rapid release of DOX triggered by low pH. Compared with free DOX, DOX/HHD exhibited relatively high cellular uptake mainly via the CD44-mediated endocytosis. The on-demand intracellular release of DOX from DOX/HHD led to improved cytotoxicity. DOX/HHD also showed great penetration efficiency in 3D tumour spheres in vitro. Moreover, these micelles with suitable particle size gained excellent tumour-targeting effects, as well as improved anti-tumour effects and reduced side effects in vivo. In conclusion, these micelles with CD44 targeted and pH-responsive behaviours provide a promising strategy for the efficient delivery of anti-tumour drugs in vivo. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 21691401 2169-141X 2169-1401 |
العلاقة: | https://doaj.org/toc/2169-1401Test; https://doaj.org/toc/2169-141XTest |
DOI: | 10.1080/21691401.2021.1884085 |
الوصول الحر: | https://doaj.org/article/17f848c0c8ff4b32b7a4d646dfd134ebTest |
رقم الانضمام: | edsdoj.17f848c0c8ff4b32b7a4d646dfd134eb |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 21691401 2169141X |
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DOI: | 10.1080/21691401.2021.1884085 |