دورية أكاديمية
Poly(Propylene Imine) Dendrimers and Amoxicillin as Dual-Action Antibacterial Agents
| العنوان: | Poly(Propylene Imine) Dendrimers and Amoxicillin as Dual-Action Antibacterial Agents |
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| المؤلفون: | Natalia Wrońska, Aleksandra Felczak, Katarzyna Zawadzka, Martyna Poszepczyńska, Sylwia Różalska, Maria Bryszewska, Dietmar Appelhans, Katarzyna Lisowska |
| المصدر: | Molecules, Vol 20, Iss 10, Pp 19330-19342 (2015) |
| بيانات النشر: | MDPI AG, 2015. |
| سنة النشر: | 2015 |
| المجموعة: | LCC:Organic chemistry |
| مصطلحات موضوعية: | poly(propylene imine) dendrimers, antibacterial activity, amoxicillin, Organic chemistry, QD241-441 |
| الوصف: | Besides acting as antimicrobial compounds, dendrimers can be considered as agents that improve the therapeutic effectiveness of existing antibiotics. In this work we present a new approach to using amoxicillin (AMX) against reference strains of common Gram-negative pathogens, alone and in combination with poly(propylene imine) (PPI) dendrimers, or derivatives thereof, in which 100% of the available hydrogen atoms are substituted with maltose (PPI 100%malG3). The concentrations of dendrimers used remained in the range non-toxic to eukaryotic cells. The results indicate that PPI dendrimers significantly enhance the antibacterial effect of amoxicillin alone, allowing antibiotic doses to be reduced. It is important to reduce doses of amoxicillin because its widespread use in medicine could lead to the development of bacterial resistance and environmental pollution. This is the first report on the combined antibacterial activity of PPI surface-modified maltose dendrimers and amoxicillin. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1420-3049 41049098 |
| العلاقة: | http://www.mdpi.com/1420-3049/20/10/19330Test; https://doaj.org/toc/1420-3049Test |
| DOI: | 10.3390/molecules201019330 |
| الوصول الحر: | https://doaj.org/article/166d25ed3f5e41049098870d03f1d797Test |
| رقم الانضمام: | edsdoj.166d25ed3f5e41049098870d03f1d797 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14203049 41049098 |
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| DOI: | 10.3390/molecules201019330 |