دورية أكاديمية
Management of Patients with Newly Diagnosed Desmoid Tumors in a First-Line Setting
| العنوان: | Management of Patients with Newly Diagnosed Desmoid Tumors in a First-Line Setting |
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| المؤلفون: | Stefano Testa, Nam Q. Bui, Gregory W. Charville, Raffi S. Avedian, Robert Steffner, Pejman Ghanouni, David G. Mohler, Kristen N. Ganjoo |
| المصدر: | Cancers, Vol 14, Iss 16, p 3907 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | desmoid tumor, active surveillance, surgery, hormonal therapy, tyrosine kinase inhibitors, cryoablation, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | The initial management of desmoid tumors (DTs) is shifting from surgery towards active surveillance, with systemic and locally ablative treatments reserved for enlarging and/or symptomatic disease. However, it remains unclear which patients would benefit most from an initial conservative rather than interventional approach. To answer this question, we retrospectively analyzed adult and pediatric patients with DTs treated at a tertiary academic cancer center between 1992 and 2022. Outcomes measured were progression-free survival (PFS) and time to next treatment (TTNT) after first-line therapy. A total of 262 treatment-naïve patients were eligible for analysis with a median age of 36.5 years (range, 0–87 years). The 5-year PFS and the median TTNT (months) after first-line treatment were, respectively: 50.6% and 69.1 mo for surgery; 64.9% and 149.5 mo for surgery plus adjuvant radiotherapy; 57.1% and 44.7 mo for surgery plus adjuvant systemic therapy; 24.9% and 4.4 mo for chemotherapy; 26.7% and 5.3 mo for hormonal therapy; 41.3% and 29.6 mo for tyrosine kinase inhibitors (TKIs); 44.4% and 8.9 mo for cryoablation and high intensity focused ultrasound; and 43.1% and 32.7 mo for active surveillance. Age ≤ 40 years (p < 0.001), DTs involving the extremities (p < 0.001), a maximum tumor diameter > 60 mm (p = 0.04), and hormonal therapy (p = 0.03) predicted a higher risk of progression. Overall, our results suggest that active surveillance should be considered initially for patients with smaller asymptomatic DTs, while upfront TKIs, local ablation, and surgery achieve similar outcomes in those with more aggressive disease. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2072-6694 84179953 |
| العلاقة: | https://www.mdpi.com/2072-6694/14/16/3907Test; https://doaj.org/toc/2072-6694Test |
| DOI: | 10.3390/cancers14163907 |
| الوصول الحر: | https://doaj.org/article/15284b64882f4dfc84179953d980594fTest |
| رقم الانضمام: | edsdoj.15284b64882f4dfc84179953d980594f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20726694 84179953 |
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| DOI: | 10.3390/cancers14163907 |