دورية أكاديمية
Therapeutic potential of anti-PIK3CG treatment for multiple myeloma via inhibiting c-Myc pathway
| العنوان: | Therapeutic potential of anti-PIK3CG treatment for multiple myeloma via inhibiting c-Myc pathway |
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| المؤلفون: | Xiaotang Di, Yiwen Pan, Jinhua Yan, Jing Liu, Doudou Wen, Hao Jiang, Shubing Zhang |
| المصدر: | Heliyon, Vol 10, Iss 1, Pp e23165- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Science (General) LCC:Social sciences (General) |
| مصطلحات موضوعية: | Multiple myeloma, PIK3CG, c-Myc, Melphalan, Targeted therapy, Science (General), Q1-390, Social sciences (General), H1-99 |
| الوصف: | Multiple myeloma (MM) is a malignant plasma cell disease. The activity of PIK3CG (PI3K catalytic subunit γ) is regulated directly by G-protein-coupled receptor and has been confirmed to be highly expressed in MM cells. This study aimed to determine the effect of pharmacological inhibition of PIK3CG on MM. We found that different concentrations of the PIK3CG inhibitor AS-605240 could suppress the growth of MM cell lines and the expression of c-Myc. The combination of PIK3CG inhibitor and the chemotherapy Melphalan could effectively inhibit the proliferation and migration of MM cells, promote the cell apoptosis, and decrease the ratio of Bcl-2/Bax and the expression of vimentin. The expression of proto-oncogene c-Myc was decreased and the sensitivity of cells to chemotherapeutic drugs was enhanced. Collectively, PIK3CG regulates growth of MM via c-Myc pathway, thus emerging as a promising molecular targeted therapy. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2405-8440 |
| العلاقة: | http://www.sciencedirect.com/science/article/pii/S2405844023103732Test; https://doaj.org/toc/2405-8440Test |
| DOI: | 10.1016/j.heliyon.2023.e23165 |
| الوصول الحر: | https://doaj.org/article/1445513486fd4851b2c5aa72cc33a940Test |
| رقم الانضمام: | edsdoj.1445513486fd4851b2c5aa72cc33a940 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24058440 |
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| DOI: | 10.1016/j.heliyon.2023.e23165 |