دورية أكاديمية
Albumin and Associated Biomarkers in Severe Neuropsychiatric Disorders: Acute-Phase Schizophrenia and Bipolar Disorder
| العنوان: | Albumin and Associated Biomarkers in Severe Neuropsychiatric Disorders: Acute-Phase Schizophrenia and Bipolar Disorder |
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| المؤلفون: | Xu H, Zheng L, Wang L, Gao H, Wei Y, Chen J |
| المصدر: | Neuropsychiatric Disease and Treatment, Vol Volume 19, Pp 2027-2037 (2023) |
| بيانات النشر: | Dove Medical Press, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Neurosciences. Biological psychiatry. Neuropsychiatry LCC:Neurology. Diseases of the nervous system |
| مصطلحات موضوعية: | schizophrenia, bipolar disorder, inflammation, albumin, neutrophil percentage-to-albumin ratio, platelet to albumin ratio, prognostic nutritional index, creatinine-albumin ratio., Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429 |
| الوصف: | Haiting Xu,1 Lina Zheng,2 Leilei Wang,1 Huanqin Gao,1 Yanyan Wei,1 Jingxu Chen1 1Psychology and Psychiatric Department, Beijing Hui-Long-Guan Hospital, Peking University, Beijing, People’s Republic of China; 2Psychology and Psychiatric Department, Liaocheng People’s Hospital, Liaocheng, People’s Republic of ChinaCorrespondence: Jingxu Chen, Email chenjx1110@163.comBackground: Inflammation is relevant to the pathophysiology of severe neuropsychiatric disorders, schizophrenia (SCZ) and bipolar disorders (BD). Multiple pathophysiological biomarkers are valuable for the study of inflammatory processes. This study investigated albumin-related biomarkers in SCZ and BD to explore their roles in disease.Methods: A total of 5,577 SCZ, 3442 BD-manic (BD-M) and 1405 BD-depression (BD-D) in acute stage and 5000 health controls (HCs) were enrolled. The differences in these biomarker levels among different groups were compared, and the contributing factors for the occurrence of SCZ, BD, and subgroups of BD were analyzed.Results: Both SCZ and BD exhibit lower prognostic nutritional index (PNI), but higher neutrophil percentage-to-albumin ratio (NPAR) and creatinine–albumin ratio (CRA) compared with HC. Compared with BD-D, BD-M had higher NPAR and platelet-to-albumin ratio (PAR) and lower CRA. In logistic regression, lower prognostic nutritional index (PNI) and higher CRA were associated with both SCZ and BD, while higher NPAR was associated with BD. In the subgroup of BD, higher NPAR, CRA and lower PNI were associated with BD-M; lower PAR, PNI and higher CRA were associated with BD-D.Conclusion: Our study reaffirmed the role of inflammation in the pathophysiology of SCZ and BD. Diagnostic value has been demonstrated in NPAR, PAR, PNI and CRA for BD and SCZ.Keywords: schizophrenia, bipolar disorder, inflammation, albumin, neutrophil percentage-to-albumin ratio, platelet to albumin ratio, prognostic nutritional index |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1178-2021 |
| العلاقة: | https://www.dovepress.com/albumin-and-associated-biomarkers-in-severe-neuropsychiatric-disorders-peer-reviewed-fulltext-article-NDTTest; https://doaj.org/toc/1178-2021Test |
| الوصول الحر: | https://doaj.org/article/144103ded3fa4054a0690bdd885feb3aTest |
| رقم الانضمام: | edsdoj.144103ded3fa4054a0690bdd885feb3a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 11782021 |
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