دورية أكاديمية
Metabolism of copper and possibilities for its regulation
| العنوان: | Metabolism of copper and possibilities for its regulation |
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| المؤلفون: | Peep Palumaa |
| المصدر: | Proceedings of the Estonian Academy of Sciences, Vol 72, Iss 4, Pp 382-392 (2023) |
| بيانات النشر: | Estonian Academy Publishers, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Science |
| مصطلحات موضوعية: | copper metabolism, wilson’s disease, menkes disease, alzheimer’s disease, copper chelation, copper ionophores, lipoid acid, Science |
| الوصف: | Copper is an indispensable biometal participating as a redox catalyst in many important biochemical processes. However, if uncontrolled, copper ions induce the formation of reactive oxygen species and become toxic. For this reason, cellular copper metabolism is tightly regulated and specific proteins â copper chaperones â participate in the metalation of cellular copper transporters and enzymes. The thermodynamic background for cellular copper distribution is known, and copper is driven to cellular destinations according to shallow affinity gradients. Copper metabolism is disturbed in the case of Wilsonâs, Menkes, and Alzheimerâs disease (AD), characterized by copper overload, deficiency, and misdistribution, respectively. Wilsonâs and Menkes disease could be treated by copper chelators and supplements, respectively; however, with AD, a search for effective molecular tools for the correction of copper metabolism is ongoing. One natural copperÂbinding ligand â αÂ-lipoic acid â has shown positive results in cellular and fruit fly models of AD and serves as a promising candidate for the regulation of copper metabolism in the case of AD. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1736-6046 1736-7530 |
| العلاقة: | https://kirj.ee/wp-content/plugins/kirj/pub/proc-4-2023-382-392_20231102003250.pdfTest; https://doaj.org/toc/1736-6046Test; https://doaj.org/toc/1736-7530Test |
| DOI: | 10.3176/proc.2023.4.03 |
| الوصول الحر: | https://doaj.org/article/1220b86ace9447498ffe3cafe5d28c1fTest |
| رقم الانضمام: | edsdoj.1220b86ace9447498ffe3cafe5d28c1f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17366046 17367530 |
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| DOI: | 10.3176/proc.2023.4.03 |