دورية أكاديمية
Hyperglycemia Is Associated with Impaired Muscle Quality in Older Men with Diabetes: The Korean Longitudinal Study on Health and Aging
| العنوان: | Hyperglycemia Is Associated with Impaired Muscle Quality in Older Men with Diabetes: The Korean Longitudinal Study on Health and Aging |
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| المؤلفون: | Ji Won Yoon, Yong-Chan Ha, Kyoung Min Kim, Jae Hoon Moon, Sung Hee Choi, Soo Lim, Young Joo Park, Jae Young Lim, Ki Woong Kim, Kyong Soo Park, Hak Chul Jang |
| المصدر: | Diabetes & Metabolism Journal, Vol 40, Iss 2, Pp 140-146 (2016) |
| بيانات النشر: | Korean Diabetes Association, 2016. |
| سنة النشر: | 2016 |
| المجموعة: | LCC:Diseases of the endocrine glands. Clinical endocrinology |
| مصطلحات موضوعية: | Aging, Diabetes mellitus, type 2, Muscle, skeletal, Sarcopenia, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| الوصف: | BackgroundThe study aimed to investigate the influence of hyperglycemia on muscle quality in older men with type 2 diabetes.MethodsThis was a subsidiary study of the Korean Longitudinal Study of Health and Aging. Among 326 older men consenting to tests of body composition and muscle strength, 269 men were ultimately analyzed after the exclusion because of stroke (n=30) and uncertainty about the diagnosis of diabetes (n=27). Body composition was measured using dual-energy X-ray absorptiometry and computed tomography. Muscle strength for knee extension was measured using an isokinetic dynamometer. Muscle quality was assessed from the ratio of leg strength to the entire corresponding leg muscle mass.ResultsThe muscle mass, strength, and quality in patients with type 2 diabetes did not differ significantly from controls. However, when patients with diabetes were subdivided according to their glycemic control status, patients with a glycosylated hemoglobin (HbA1c) level of ≥8.5% showed significantly decreased leg muscle quality by multivariate analysis (odds ratio, 4.510; P=0.045) after adjustment for age, body mass index, smoking amount, alcohol consumption, physical activity, and duration of diabetes. Physical performance status was also impaired in subjects with an HbA1c of ≥8.5%.ConclusionPoor glycemic control in these older patients with diabetes was associated with significant risk of decreased muscle quality and performance status. Glycemic control with an HbA1c of |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2233-6079 2233-6087 |
| العلاقة: | https://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-40-140.pdfTest; https://doaj.org/toc/2233-6079Test; https://doaj.org/toc/2233-6087Test |
| DOI: | 10.4093/dmj.2016.40.2.140 |
| الوصول الحر: | https://doaj.org/article/11a8dd4704a842cf968416631a84c30dTest |
| رقم الانضمام: | edsdoj.11a8dd4704a842cf968416631a84c30d |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22336079 22336087 |
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| DOI: | 10.4093/dmj.2016.40.2.140 |