دورية أكاديمية
An unusual case of primary hepatic lymphoma with dramatic but unsustained response to bendamustine plus rituximab and literature review
| العنوان: | An unusual case of primary hepatic lymphoma with dramatic but unsustained response to bendamustine plus rituximab and literature review |
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| المؤلفون: | Sih-Han Liao, Yin-Kai Chen, Shan-Chi Yu, Ming-Shiang Wu, Hsiu-Po Wang, Ping-Huei Tseng |
| المصدر: | SAGE Open Medical Case Reports, Vol 5 (2017) |
| بيانات النشر: | SAGE Publishing, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Medicine (General) |
| مصطلحات موضوعية: | Medicine (General), R5-920 |
| الوصف: | Objectives: Primary hepatic lymphoma is an uncommon cause of hepatic space-occupying lesions. Methods: We describe the case of a 73-year-old man with primary hepatic lymphoma, who presented with a low-grade fever and lower limb weakness which had progressed in the past 2 months. Results: Abdominal ultrasound and computed tomography showed multiple small hepatic tumors. Echo-guided biopsy of the hepatic tumor demonstrated primary hepatic diffuse large B cell lymphoma. Moreover, bone marrow was uninvolved, but the bone marrow smear disclosed hemophagocytosis, which is uncommon in diffuse large B cell lymphoma. Chemotherapy with bendamustine and rituximab treatment was initiated with a dramatic response: hepatic tumors markedly shrank in size shown by follow-up computed tomography and the patient returned to his normal life. Nevertheless, the response was sustained for only 8 months. Finally, the disease resisted further chemotherapy and this patient died of a severe Klebsiella pneumoniae infection. Conclusion: Chemotherapy with bendamustine and rituximab has shown a dramatic, but not durable, response in the present case with old age and multiple comorbidities. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2050-313X 2050313X |
| العلاقة: | https://doaj.org/toc/2050-313XTest |
| DOI: | 10.1177/2050313X17709190 |
| الوصول الحر: | https://doaj.org/article/104faa994185446a81d670a2a405fbbdTest |
| رقم الانضمام: | edsdoj.104faa994185446a81d670a2a405fbbd |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2050313X |
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| DOI: | 10.1177/2050313X17709190 |