دورية أكاديمية
Blood perfusion with polymyxin B immobilized columns in patients with COVID-19 requiring oxygen therapy
| العنوان: | Blood perfusion with polymyxin B immobilized columns in patients with COVID-19 requiring oxygen therapy |
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| المؤلفون: | Daisuke Katagiri, Akinari Tsukada, Shinyu Izumi, Yosuke Shimizu, Junko Terada-Hirashima, Yukari Uemura, Yusaku Kusaba, Jin Takasaki, Hiroyuki Takoi, Miwa Tamura-Nakano, Masayuki Hojo, Hideki Takano, Eisei Noiri, Shinji Abe, Arata Azuma, Haruhito Sugiyama |
| المصدر: | Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024) |
| بيانات النشر: | Nature Portfolio, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Abstract Extracorporeal blood purification with polymyxin B immobilized fiber column direct hemoperfusion (PMX-DHP), is reported to be effective in treating COVID-19 pneumonitis with oxygen demand. This multicenter prospective study evaluated the efficacy and safety of PMX-DHP in oxygen-requiring patients with COVID-19 admitted between September 28, 2020, and March 31, 2022. The primary endpoint was the percentage of clinical improvement 15 days after treatment. The secondary endpoint was the percentage of worsened disease status. Data from the COVID-19 patient registry were used for the synthetic control group. The improvement rate on Day 15 did not differ between PMX-treated patients and controls; however, the deterioration rate was 0.38 times lower in the PMX-treated group, and the death rates on Day 29 were 0 and 11.1% in the PMX-treated and control groups, respectively. The PMX group showed a 0.73 times higher likelihood for reduced intensive care demand, as 16.7% of PMX-treated patients and 22.8% of controls worsened. After treatment blood oxygenation improved, urinary β2-microglobulin and liver-type fatty acid-binding protein showed significant decreases, and IL-6 decreased once during treatment but did not persist. In this study, PMX treatment effectively prevented the worsening of COVID-19 pathology, accompanied by improved oxygenation. PMX treatment to remove activated cells may effectively improve patient outcomes. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-2322 |
| العلاقة: | https://doaj.org/toc/2045-2322Test |
| DOI: | 10.1038/s41598-024-63330-2 |
| الوصول الحر: | https://doaj.org/article/0f3fd252378a41399daa30ac9d452914Test |
| رقم الانضمام: | edsdoj.0f3fd252378a41399daa30ac9d452914 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-024-63330-2 |