دورية أكاديمية
Discovery of proangiogenic CD44+mesenchymal cancer stem cells in an acute myeloid leukemia patient’s bone marrow
| العنوان: | Discovery of proangiogenic CD44+mesenchymal cancer stem cells in an acute myeloid leukemia patient’s bone marrow |
|---|---|
| المؤلفون: | Huynh Cao, Jeffrey Xiao, Mark E. Reeves, Kimberly Payne, Chien Shing Chen, David J. Baylink, Guido Marcucci, Yi Xu |
| المصدر: | Journal of Hematology & Oncology, Vol 13, Iss 1, Pp 1-4 (2020) |
| بيانات النشر: | BMC, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Diseases of the blood and blood-forming organs LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | Acute myeloid leukemia, Mesenchymal stem cells, Mesenchymal cancer stem cells, CD44, Angiogenesis, Microenvironment, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Abstract Here, we report a unique acute myeloid leukemia (AML) bone marrow-derived mesenchymal stem cell (MSC) with both mesenchymal and endothelial potential, which we have named Mesenchymal Cancer Stem Cells (MCSCs). These MCSCs are CD90-CD13-CD44+ and differ from MSCs in isolation, expansion, differentiation, immunophenotype, and cytokine release profile. Furthermore, blocking CD44 inhibited the proliferation and cluster formation of early MCSCs with lower ICAM-1 protein levels. Similar CD90-CD44+ cancer stem cells have been reported in both gastric and breast cancers, which grew in floating spheres in vitro and exhibited mesenchymal features and high metastatic/tumorigenic capabilities in vivo. Our novel discovery provides the first evidence that certain AMLs may be comprised of both hematopoietic and stromal malignant cells. Targeting MCSCs and their cytokine release has potential as a novel therapeutic approach in AML. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1756-8722 |
| العلاقة: | http://link.springer.com/article/10.1186/s13045-020-00899-xTest; https://doaj.org/toc/1756-8722Test |
| DOI: | 10.1186/s13045-020-00899-x |
| الوصول الحر: | https://doaj.org/article/0e82795f0dfb412d9904bec2447fef6fTest |
| رقم الانضمام: | edsdoj.0e82795f0dfb412d9904bec2447fef6f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17568722 |
|---|---|
| DOI: | 10.1186/s13045-020-00899-x |