دورية أكاديمية
Maternal Mediterranean diet in pregnancy and newborn DNA methylation: a meta-analysis in the PACE Consortium
| العنوان: | Maternal Mediterranean diet in pregnancy and newborn DNA methylation: a meta-analysis in the PACE Consortium |
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| المؤلفون: | Leanne K. Küpers, Sílvia Fernández-Barrés, Aayah Nounu, Chloe Friedman, Ruby Fore, Giulia Mancano, Dana Dabelea, Sheryl L. Rifas-Shiman, Rosa H. Mulder, Emily Oken, Laura Johnson, Mariona Bustamante, Vincent W.V. Jaddoe, Marie-France Hivert, Anne P. Starling, Jeanne H.M. de Vries, Gemma C. Sharp, Martine Vrijheid, Janine F. Felix |
| المصدر: | Epigenetics, Vol 17, Iss 11, Pp 1419-1431 (2022) |
| بيانات النشر: | Taylor & Francis Group, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Genetics |
| مصطلحات موضوعية: | epigenetics, epigenome-wide association study, dna methylation, mediterranean diet, prenatal diet, maternal diet, newborn, cord blood, Genetics, QH426-470 |
| الوصف: | Higher adherence to the Mediterranean diet during pregnancy is related to a lower risk of preterm birth and to better offspring cardiometabolic health. DNA methylation may be an underlying biological mechanism. We evaluated whether maternal adherence to the Mediterranean diet was associated with offspring cord blood DNA methylation. We meta-analysed epigenome-wide association studies (EWAS) of maternal adherence to the Mediterranean diet during pregnancy and offspring cord blood DNA methylation in 2802 mother–child pairs from five cohorts. We calculated the relative Mediterranean diet (rMED) score with range 0–18 and an adjusted rMED excluding alcohol (rMEDp, range 0–16). DNA methylation was measured using Illumina 450K arrays. We used robust linear regression modelling adjusted for child sex, maternal education, age, smoking, body mass index, energy intake, batch, and cell types. We performed several functional analyses and examined the persistence of differential DNA methylation into childhood (4.5–7.8 y). rMEDp was associated with cord blood DNA methylation at cg23757341 (0.064% increase in DNA methylation per 1-point increase in the rMEDp score, SE = 0.011, P = 2.41 × 10−8). This cytosine–phosphate–guanine (CpG) site maps to WNT5B, associated with adipogenesis and glycaemic phenotypes. We did not identify associations with childhood gene expression, nor did we find enriched biological pathways. The association did not persist into childhood. In this meta-analysis, maternal adherence to the Mediterranean diet (excluding alcohol) during pregnancy was associated with cord blood DNA methylation level at cg23757341. Potential mediation of DNA methylation in associations with offspring health requires further study. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1559-2294 1559-2308 15592294 |
| العلاقة: | https://doaj.org/toc/1559-2294Test; https://doaj.org/toc/1559-2308Test |
| DOI: | 10.1080/15592294.2022.2038412 |
| الوصول الحر: | https://doaj.org/article/e0d735dca83d44d6b853574906f0851eTest |
| رقم الانضمام: | edsdoj.0d735dca83d44d6b853574906f0851e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 15592294 15592308 |
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| DOI: | 10.1080/15592294.2022.2038412 |