دورية أكاديمية
Current clinical application of dantrolene sodium
| العنوان: | Current clinical application of dantrolene sodium |
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| المؤلفون: | Hong Seuk Yang, Jae Moon Choi, Junyong In, Tae-yun Sung, Yong Beom Kim, Shofina Sultana |
| المصدر: | Anesthesia and Pain Medicine, Vol 18, Iss 3, Pp 220-232 (2023) |
| بيانات النشر: | Korean Society of Anesthesiologists, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Anesthesiology LCC:Medicine |
| مصطلحات موضوعية: | adverse events, dantrolene, malignant hyperthermia, pharmacology, ryanodine receptor calcium release channel, Anesthesiology, RD78.3-87.3, Medicine |
| الوصف: | Dantrolene sodium (DS) was first introduced as an oral antispasmodic drug. However, in 1975, DS was demonstrated to be effective for managing malignant hyperthermia (MH) and was adopted as the primary therapeutic drug after intravenous administration. However, it is difficult to administer DS intravenously to manage MH. MH is life-threatening, pharmacogenomically related, and induced by depolarizing neuromuscular blocking agents or inhalational anesthetics. All anesthesiologists should know the pharmacology of DS. DS suppresses Ca2+ release from ryanodine receptors (RyRs). RyRs are expressed in various tissues, although their distribution differs among subtypes. The anatomical and physiological functions of RyRs have also been demonstrated as effective therapeutic drugs for cardiac arrhythmias, Alzheimer’s disease, and other RyR-related diseases. Recently, a new formulation was introduced that enhanced the hydrophilicity of the lipophilic DS. The authors summarize the pharmacological properties of DS and comment on its indications, contraindications, adverse effects, and interactions with other drugs by reviewing reference articles. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1975-5171 2383-7977 |
| العلاقة: | http://www.anesth-pain-med.org/upload/pdf/apm-22260.pdfTest; https://doaj.org/toc/1975-5171Test; https://doaj.org/toc/2383-7977Test |
| DOI: | 10.17085/apm.22260 |
| الوصول الحر: | https://doaj.org/article/0d033b0d2477405ca79b7fa689636143Test |
| رقم الانضمام: | edsdoj.0d033b0d2477405ca79b7fa689636143 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19755171 23837977 |
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| DOI: | 10.17085/apm.22260 |