دورية أكاديمية
Alterations of HDL particles in children with end-stage renal disease
| العنوان: | Alterations of HDL particles in children with end-stage renal disease |
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| المؤلفون: | Stefanović Aleksandra, Ristovski-Kornic Danijela, Kotur-Stevuljević Jelena, Spasojević-Kalimanovska Vesna, Vekić Jelena, Miljković Milica, Paripović Dušan, Peco-Antić Amira, Jelić-Ivanović Zorana, Zeljković Aleksandra |
| المصدر: | Journal of Medical Biochemistry, Vol 36, Iss 4, Pp 358-365 (2017) |
| بيانات النشر: | Society of Medical Biochemists of Serbia, Belgrade, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Biochemistry |
| مصطلحات موضوعية: | chronic kidney disease, hdl particles, myeloperoxidase, Biochemistry, QD415-436 |
| الوصف: | Background: Unfavorable lipid profile presents one of most important risk factor for cardiovascular disease in renal pathology. Myeloperoxidase (MPO) as enzyme which oxidizes lipoproteins and paraoxonase1 (PON1) as anti-oxidative enzyme have been involved in pathogenesis of cardiovascular disease. In the present study we sought to assess oxidative stress status, lipoprotein subclasses distribution as well as functionality of high density lipoprotein (HDL) trough M PO/PON1 ratio in children with chronic kidney disease (CKD) and children after renal transplantation. Methods: PON1 activity and oxidative stress parameters were measured spectrophotometrically, while MPO concentration was determined using immunoassay. Separation of lipoprotein subclasses was performed by vertical gradient gel electrophoresis in 19 children with different stage of CKD and 19 post-transplantation patients (PT). Results: CKD patients had increased MPO/PON1 ratio and higher prevalence of smaller HDL subclasses when compared to PT subjects. Also, there was a significant positive correlation between MPO level and MPO/PON1 ratio with relative proportion of smaller HDL subclasses. Conclusions: Children with CKD have impaired HDL distribution that is improved after kidney transplantation. Since that measurement of HDL distribution and functionality are not routinely available, MPO/PON1 ratio may be useful marker that could provide necessary information. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1452-8258 1452-8266 |
| العلاقة: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2017/1452-82581704358S.pdfTest; https://doaj.org/toc/1452-8258Test; https://doaj.org/toc/1452-8266Test |
| الوصول الحر: | https://doaj.org/article/0be44f44cf544d2780e26735acc83262Test |
| رقم الانضمام: | edsdoj.0be44f44cf544d2780e26735acc83262 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14528258 14528266 |
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