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EGFR and EGFRvIII Promote Angiogenesis and Cell Invasion in Glioblastoma: Combination Therapies for an Effective Treatment

التفاصيل البيبلوغرافية
العنوان: EGFR and EGFRvIII Promote Angiogenesis and Cell Invasion in Glioblastoma: Combination Therapies for an Effective Treatment
المؤلفون: Stefanie Keller, Mirko H. H. Schmidt
المصدر: International Journal of Molecular Sciences, Vol 18, Iss 6, p 1295 (2017)
بيانات النشر: MDPI AG, 2017.
سنة النشر: 2017
المجموعة: LCC:Biology (General)
LCC:Chemistry
مصطلحات موضوعية: glioblastoma multiforme, invasion, angiogenesis, EGFR, EGFRvIII, Biology (General), QH301-705.5, Chemistry, QD1-999
الوصف: Epidermal growth factor receptor (EGFR) and the mutant EGFRvIII are major focal points in current concepts of targeted cancer therapy for glioblastoma multiforme (GBM), the most malignant primary brain tumor. The receptors participate in the key processes of tumor cell invasion and tumor-related angiogenesis and their upregulation correlates with the poor prognosis of glioma patients. Glioma cell invasion and increased angiogenesis share mechanisms of the degradation of the extracellular matrix (ECM) through upregulation of ECM-degrading proteases as well as the activation of aberrant signaling pathways. This review describes the role of EGFR and EGFRvIII in those mechanisms which might offer new combined therapeutic approaches targeting EGFR or EGFRvIII together with drug treatments against proteases of the ECM or downstream signaling to increase the inhibitory effects of mono-therapies.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1422-0067
العلاقة: http://www.mdpi.com/1422-0067/18/6/1295Test; https://doaj.org/toc/1422-0067Test
DOI: 10.3390/ijms18061295
الوصول الحر: https://doaj.org/article/0818c9aeace14aa1a86ccfd97f668428Test
رقم الانضمام: edsdoj.0818c9aeace14aa1a86ccfd97f668428
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14220067
DOI:10.3390/ijms18061295