دورية أكاديمية
Immune‐related adverse events in hepatitis treated with thiopurine‐based immunosuppressants: A case report
| العنوان: | Immune‐related adverse events in hepatitis treated with thiopurine‐based immunosuppressants: A case report |
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| المؤلفون: | Keita Kawakado, Kazuhisa Nakashima, Hiroshi Tobita, Mamiko Nagase, Ken Yoshihara, Mika Horie, Megumi Hamaguchi, Tamio Okimoto, Yukari Tsubata, Takeshi Isobe |
| المصدر: | Thoracic Cancer, Vol 14, Iss 13, Pp 1208-1211 (2023) |
| بيانات النشر: | Wiley, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | azathioprine, hepatitis, immune‐related events, mercaptopurine, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Abstract An 82‐year‐old man was treated with ipilimumab and nivolumab for malignant pleural mesothelioma. Although he was previously treated with prednisolone (1 mg/kg/day) for immune‐related adverse event (irAE) hepatitis by a previous doctor, he still had worsening liver function and was transferred to our hospital. Blood tests and imaging findings were negative for autoimmune and infectious hepatitis, and liver biopsy results were consistent with irAE hepatitis. Steroid pulse therapy improved liver function, but tapering to prednisolone (1 mg/kg/day) again worsened his liver function. Concomitant use of mycophenolate mofetil was initiated, but no improvement in liver function was observed, therefore azathioprine, a thiopurine immunosuppressant, was administered in combination with steroids. During the course of treatment, hepatic dysfunction due to azathioprine was suspected, and the concomitant use of mercaptopurine and prednisolone was started. Afterward, the liver function improved, and the prednisolone dose was gradually reduced to 10 mg/day. This is a rare case in which a thiopurine‐based immunosuppressant was effective against irAE hepatitis, therefore thiopurine‐based immunosuppressants may be effective against steroid‐refractory hepatitis. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1759-7714 1759-7706 |
| العلاقة: | https://doaj.org/toc/1759-7706Test; https://doaj.org/toc/1759-7714Test |
| DOI: | 10.1111/1759-7714.14859 |
| الوصول الحر: | https://doaj.org/article/069c49e3f4ec4a7991adac1b3b78145dTest |
| رقم الانضمام: | edsdoj.069c49e3f4ec4a7991adac1b3b78145d |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17597714 17597706 |
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| DOI: | 10.1111/1759-7714.14859 |