دورية أكاديمية
TGF-β1 polymorphism in American tegumentary leishmaniasis in a Southern Brazilian population
| العنوان: | TGF-β1 polymorphism in American tegumentary leishmaniasis in a Southern Brazilian population |
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| المؤلفون: | Fabiane Vieira Berg Shehadeh, Rosiane Ribeiro dos Santos, Laiane Alzira Denski da Silva, Waldir Veríssimo da Silva Júnior, Rejane Ribas-Silva, Adriana Danmvolf Ribas, Thaís Gomes Verzignassi Silveira, Sueli Donizete Borelli, Sandra Mara Alessi Aristides |
| المصدر: | Revista da Sociedade Brasileira de Medicina Tropical, Vol 52, Iss 0 (2019) |
| بيانات النشر: | Sociedade Brasileira de Medicina Tropical (SBMT), 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Arctic medicine. Tropical medicine |
| مصطلحات موضوعية: | Cutaneous leishmaniasis, Genotyping, Gene polymorphisms, Cytokines, Arctic medicine. Tropical medicine, RC955-962 |
| الوصف: | Abstract INTRODUCTION: Genetic polymorphisms define the cytokine production leading to susceptibility or resistance to diseases. We studied the cytokine polymorphism in the development of tegumentary leishmaniasis (TL). METHODS: Genotyping of TNF-α, TGF-β1, IFN-γ, IL-6, and IL-10 were performed by polymerase chain reaction assay. RESULTS: G and C alleles of TGF- β1 (codon 25) were the most common in controls and patients, respectively. G/G was the most frequent genotype in controls, and G/C and C/C in patients. CONCLUSIONS: G/G genotype of codon 25 in TGF-β1 appeared to confer resistance, and G/C and C/C genotypes, susceptibility to TL in this population. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1678-9849 0037-8682 |
| العلاقة: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822019000100610&lng=en&tlng=enTest; https://doaj.org/toc/1678-9849Test |
| DOI: | 10.1590/0037-8682-0415-2017 |
| الوصول الحر: | https://doaj.org/article/069a47c78ec346f781faa623202860abTest |
| رقم الانضمام: | edsdoj.069a47c78ec346f781faa623202860ab |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 16789849 00378682 |
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| DOI: | 10.1590/0037-8682-0415-2017 |