دورية أكاديمية
High-Pressure Carbon Monoxide and Oxygen Mixture is Effective for Lung Preservation
| العنوان: | High-Pressure Carbon Monoxide and Oxygen Mixture is Effective for Lung Preservation |
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| المؤلفون: | Atsushi Fujiwara, Naoyuki Hatayama, Natsumi Matsuura, Naoya Yokota, Kaori Fukushige, Tomiko Yakura, Shintaro Tarumi, Tetsuhiko Go, Shuichi Hirai, Munekazu Naito, Hiroyasu Yokomise |
| المصدر: | International Journal of Molecular Sciences, Vol 20, Iss 11, p 2719 (2019) |
| بيانات النشر: | MDPI AG, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | carbon monoxide, lung preservation, ischemia–reperfusion injury, high-pressure gas, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | (1) Background: Heme oxygenase-1 (HO-1) degrades heme and generates carbon monoxide (CO), producing various anti-inflammatory, anti-oxidative, and anti-apoptotic effects. This study aimed to confirm the effects of CO on the ischemia−reperfusion injury (IRI) of donor lungs using a high-pressure gas (HPG) preservation method. (2) Methods: Donor rat and canine lungs were preserved in a chamber filled with CO (1.5 atm) and oxygen (O2; 2 atm) and were ventilated with either CO and O2 mixture (CO/O2 group) or air (air group) immediately before storage. Rat lungs were subjected to heterotopic cervical transplantation and evaluated after reperfusion, whereas canine lungs were subjected to allogeneic transplantation and evaluated. (3) Results: Alveolar hemorrhage in the CO/O2 group was significantly milder than that in the air group. mRNA expression levels of HO-1 remained unchanged in both the groups; however, inflammatory mediator levels were significantly lower in the CO/O2 group than in the air group. The oxygenation of graft lungs was comparable between the two groups, but lactic acid level tended to be higher in the air group. (4) Conclusions: The HO-1/CO system in the HPG preservation method is effective in suppressing IRI and preserving donor lungs. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 |
| العلاقة: | https://www.mdpi.com/1422-0067/20/11/2719Test; https://doaj.org/toc/1422-0067Test |
| DOI: | 10.3390/ijms20112719 |
| الوصول الحر: | https://doaj.org/article/06811ee2167c4e78a16d3c4791198b08Test |
| رقم الانضمام: | edsdoj.06811ee2167c4e78a16d3c4791198b08 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 |
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| DOI: | 10.3390/ijms20112719 |