دورية أكاديمية
Serum growth differentiation factor 15 is closely associated with metabolic abnormalities in Chinese pregnant women
| العنوان: | Serum growth differentiation factor 15 is closely associated with metabolic abnormalities in Chinese pregnant women |
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| المؤلفون: | Enhao Li, Peihong Chen, Jun Lu, Jiarong Dai, Jufen Yi, Shan Zhang, Hua Jin, Meixiang Guo, Hongtao Wang, Xuemei Yu |
| المصدر: | Journal of Diabetes Investigation, Vol 12, Iss 8, Pp 1501-1507 (2021) |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Diseases of the endocrine glands. Clinical endocrinology |
| مصطلحات موضوعية: | Gestational diabetes, Growth differentiation factor 15, Metabolic abnormalities, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| الوصف: | Abstract Aims To explore the relationship between serum growth differentiation factor 15 (GDF15) and metabolic abnormalities in Chinese pregnant women. Materials and Methods We recruited 200 patients with gestational diabetes mellitus (GDM) and 211 matched normal control within 24–28 weeks of pregnancy. Enzyme‐linked immunosorbent assay (ELISA) was used to determine the serum GDF15 levels of all participants. Then we grouped participants according to the number of metabolic abnormalities (including blood glucose, blood lipids and blood pressure), divided them into a normal metabolic group, one metabolic abnormality group, two or more metabolic abnormalities group. Finally, multinomial logistic regression analysis was used to estimate the odds radio (OR) and 95% CIs expressing the association between GDF15 and metabolic abnormalities in pregnant women. Results Through bivariate correlation analysis, we found that serum GDF15 is linearly correlated with glucose metabolism indices, such as 1h‐PG, 2h‐PG, HbA1c (all P 1), and the risk of multiple metabolic abnormalities was higher. As the number of metabolic abnormalities increased, serum GDF15 levels also were elevated (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2040-1124 2040-1116 |
| العلاقة: | https://doaj.org/toc/2040-1116Test; https://doaj.org/toc/2040-1124Test |
| DOI: | 10.1111/jdi.13488 |
| الوصول الحر: | https://doaj.org/article/018d56ccc11f4b4cbceb747e8f45bd48Test |
| رقم الانضمام: | edsdoj.018d56ccc11f4b4cbceb747e8f45bd48 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20401124 20401116 |
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| DOI: | 10.1111/jdi.13488 |