دورية أكاديمية
Plasma porphyrins among end stage renal disease patients and cutaneous symptoms- is there still an association?
| العنوان: | Plasma porphyrins among end stage renal disease patients and cutaneous symptoms- is there still an association? |
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| المؤلفون: | Shira Goldman, Omri Zidan, Yonatan Edel, Amir Schechter, Tomer Mimouni, Emmilia Hodak, Sharon Cohen, Rivka Mamet, Benaya Rozen-Zvi, Assi Levi |
| المصدر: | Molecular Genetics and Metabolism Reports, Vol 33, Iss , Pp 100928- (2022) |
| بيانات النشر: | Elsevier, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine (General) LCC:Biology (General) |
| مصطلحات موضوعية: | Dialysis, Porphyria, Cutaneous symptoms, Medicine (General), R5-920, Biology (General), QH301-705.5 |
| الوصف: | Introduction: Several abnormalities of porphyrin metabolism leading to Porphyria Cutanea Tarda (PCT) have been described in early studies of End Stage Renal Disease (ESRD) patients, with a reported prevalence of 5–18%. We aimed to evaluate porphyrin levels and correlation to skin manifestations in modern dialysis era. Methods: The study cohort included adult hemodialysis patients from a single center tertiary medical center. All patients underwent a full skin examination, completed the Dermatology Life Quality Index questioner, and provided a blood sample for porphyrin levels assessment. Results: A total of 94 adult hemodialysis patients were recruited to the study. No clinical PCT was diagnosed. Porphyrin levels did not correlate with any clinical or dialysis quality parameters. Conclusions: In modern hemodialysis era, possibly due to improved porphyrins' metabolism and dialysis removal, PCT is much less prevalent among hemodialysis patients than previously reported in the past. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2214-4269 |
| العلاقة: | http://www.sciencedirect.com/science/article/pii/S221442692200088XTest; https://doaj.org/toc/2214-4269Test |
| DOI: | 10.1016/j.ymgmr.2022.100928 |
| الوصول الحر: | https://doaj.org/article/e007eb900b7f43809a72bad669e2a6baTest |
| رقم الانضمام: | edsdoj.007eb900b7f43809a72bad669e2a6ba |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22144269 |
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| DOI: | 10.1016/j.ymgmr.2022.100928 |