دورية أكاديمية
CMTM6 significantly relates to PD-L1 and predicts the prognosis of gastric cancer patients
| العنوان: | CMTM6 significantly relates to PD-L1 and predicts the prognosis of gastric cancer patients |
|---|---|
| المؤلفون: | Li, Xin, Chen, Ling, Gu, Chuan, Sun, Qiaoli, Li, Jia |
| المساهمون: | Shanghai Municipal Education Commission, National Clinical Research Base of Traditional Chinese Medicine, Yueyang Hospital of Integrated Traditional Chinese, Shanghai University of Traditional Chinese Medicine |
| المصدر: | PeerJ ; volume 8, page e9536 ; ISSN 2167-8359 |
| بيانات النشر: | PeerJ |
| سنة النشر: | 2020 |
| المجموعة: | PeerJ (E-Journal - via CrossRef) |
| الوصف: | Background The CKLF-like MARVEL transmembrane domain containing 6 (CMTM6) is a key regulator of the programed death receptor ligand-1 (PD-L1) protein. However, the usefulness of CMTM6 expression as a prognostic indicator and the relationship between CMTM6 and PD-L1 expression in gastric cancer (GC) remains unclear. Objectives We evaluated the expression and prognostic implications of CMTM6 in GC tissue and its relationship with PD-L1 expression. Patients and methods The protein expressions of CMTM6 and PD-L1 were detected in 122 cases of postoperative GC tissue using immunohistochemical (IHC) assays. Kaplan–Meier survival analysis was used to calculate the survival probability and a log-rank test was used to compare the survival curves. Univariate and multivariate Cox proportional hazard regression analyses were used to evaluate the clinically-related factors associated with survival. Pearson’s correlation was used to determine the correlation analysis and estimate the statistical significance. The univariate and multivariate logistic regression analyses were used to analyze the relationship between clinically-related factors and PD-L1 expression. Results Kaplan–Meier survival analysis showed that patients with high CMTM6 expression had shorter overall survival (OS) than those with low expression ( P < 0.001). The expression of CMTM6 was an independent risk factor for prognosis in multivariate Cox proportional hazard regression analyses (HR:2.221, CI% [1.36–3.628], P = 0.001). The OS of patients with positively expressed PD-L1 was significantly shorter than those with negatively expressed PD-L1 ( P = 0.003). The expression of CMTM6 was significantly related to the positive expression of PD-L1 in gastric cancer tissues ( r = 0.186, P = 0.041). The expression of CMTM6 was the independent risk factor for PD-L1 expression in multivariate logistic regression analysis (OR:2.538, CI% [1.128–5.714], P = 0.024). Conclusion CMTM6 expression is significantly related to PD-L1 and may be a useful prognostic indicator and ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.7717/peerj.9536 |
| الإتاحة: | https://doi.org/10.7717/peerj.9536Test https://peerj.com/articles/9536.pdfTest https://peerj.com/articles/9536.xmlTest https://peerj.com/articles/9536.htmlTest |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.FFC6197F |
| قاعدة البيانات: | BASE |
| DOI: | 10.7717/peerj.9536 |
|---|