دورية أكاديمية
Epigenetic clocks in relapse after a first episode of schizophrenia
| العنوان: | Epigenetic clocks in relapse after a first episode of schizophrenia |
|---|---|
| المؤلفون: | Segura, Alex-Gonzalez, Prohens, Llucia, Mezquida, Gisela, Amoretti, Silvia, Bioque, Miquel, Ribeiro, Maria, Gurriaran-Bas, Xaquin, Rementeria, Lide, Berge, Daniel, Rodriguez-Jimenez, Roberto, Roldan, Alexandra, Pomarol-Clotet, Edith, Ibanez, Angela, Usall, Judith, Garcia-Portilla, Maria Paz, Cuesta, Manuel J., Parellada, Mara, Gonzalez-Pinto, Ana, Berrocoso, Esther, Bernardo, Miquel, Mas, Sergi, 2EPS Grp |
| المساهمون: | Segura, Alex-Gonzalez Univ Barcelona, Dept Clin Fdn, Pharmacol Unit, Barcelona, Spain, Prohens, Llucia Univ Barcelona, Dept Clin Fdn, Pharmacol Unit, Barcelona, Spain, Mezquida, Gisela Univ Barcelona, Dept Clin Fdn, Pharmacol Unit, Barcelona, Spain, Mas, Sergi Univ Barcelona, Dept Clin Fdn, Pharmacol Unit, Barcelona, Spain, Segura, Alex-Gonzalez Inst Invest Biomed August Pi & Sunyer IDIBAPs, Barcelona, Spain, Prohens, Llucia Inst Invest Biomed August Pi & Sunyer IDIBAPs, Barcelona, Spain, Mezquida, Gisela Inst Invest Biomed August Pi & Sunyer IDIBAPs, Barcelona, Spain, Amoretti, Silvia Inst Invest Biomed August Pi & Sunyer IDIBAPs, Barcelona, Spain, Bioque, Miquel Inst Invest Biomed August Pi & Sunyer IDIBAPs, Barcelona, Spain, Bernardo, Miquel Inst Invest Biomed August Pi & Sunyer IDIBAPs, Barcelona, Spain, Mas, Sergi Inst Invest Biomed August Pi & Sunyer IDIBAPs, Barcelona, Spain, Mezquida, Gisela Hosp Clin Barcelona, Neurosci Inst, Barcelona Clin Schizophrenia Unit BCSU, Barcelona, Spain, Amoretti, Silvia Hosp Clin Barcelona, Neurosci Inst, Barcelona Clin Schizophrenia Unit BCSU, Barcelona, Spain, Bioque, Miquel Hosp Clin Barcelona, Neurosci Inst, Barcelona Clin Schizophrenia Unit BCSU, Barcelona, Spain, Bernardo, Miquel Hosp Clin Barcelona, Neurosci Inst, Barcelona Clin Schizophrenia Unit BCSU, Barcelona, Spain, Mezquida, Gisela Ctr Invest Biomed Red Salud Mental CIBERSAM, Barcelona, Spain, Amoretti, Silvia Ctr Invest Biomed Red Salud Mental CIBERSAM, Barcelona, Spain, Bioque, Miquel Ctr Invest Biomed Red Salud Mental CIBERSAM, Barcelona, Spain, Gurriaran-Bas, Xaquin Ctr Invest Biomed Red Salud Mental CIBERSAM, Barcelona, Spain, Berge, Daniel Ctr Invest Biomed Red Salud Mental CIBERSAM, Barcelona, Spain, Rodriguez-Jimenez, Roberto Ctr Invest Biomed Red Salud Mental CIBERSAM, Barcelona, Spain, Pomarol-Clotet, Edith Ctr Invest Biomed Red Salud Mental CIBERSAM, Barcelona, Spain, Ibanez, Angela Ctr Invest Biomed Red Salud Mental CIBERSAM, Barcelona, Spain, Garcia-Portilla, Maria Paz Ctr Invest Biomed Red Salud Mental CIBERSAM, Barcelona, Spain, Cuesta, Manuel J. Ctr Invest Biomed Red Salud Mental CIBERSAM, Barcelona, Spain, Parellada, Mara Ctr Invest Biomed Red Salud Mental CIBERSAM, Barcelona, Spain, Gonzalez-Pinto, Ana Ctr Invest Biomed Red Salud Mental CIBERSAM, Barcelona, Spain, Berrocoso, Esther Ctr Invest Biomed Red Salud Mental CIBERSAM, Barcelona, Spain, Bernardo, Miquel Ctr Invest Biomed Red Salud Mental CIBERSAM, Barcelona, Spain, Mas, Sergi Ctr Invest Biomed Red Salud Mental CIBERSAM, Barcelona, Spain, Bioque, Miquel Univ Barcelona, Dept Med, Barcelona, Spain, Bernardo, Miquel Univ Barcelona, Dept Med, Barcelona, Spain, Ribeiro, Maria Complejo Hosp Navarra, Dept Psychiat, Pamplona, Spain, Cuesta, Manuel J. Complejo Hosp Navarra, Dept Psychiat, Pamplona, Spain, Ribeiro, Maria Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain, Cuesta, Manuel J. Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain, Gurriaran-Bas, Xaquin Univ Complutense, Hosp Gen Univ Gregorio Maranon, Sch Med,IiSGM, Inst Psychiat & Mental Hlth,Dept Child & Adolesce, Madrid, Spain, Parellada, Mara Univ Complutense, Hosp Gen Univ Gregorio Maranon, Sch Med,IiSGM, Inst Psychiat & Mental Hlth,Dept Child & Adolesce, Madrid, Spain, Rementeria, Lide Hosp Univ Alava, Dept Psychiat, Vitoria, Spain, Gonzalez-Pinto, Ana Hosp Univ Alava, Dept Psychiat, Vitoria, Spain, Rementeria, Lide Ctr Invest Biomed Red Salud Mental CIBERSAM, Vitoria, Spain, Gonzalez-Pinto, Ana Ctr Invest Biomed Red Salud Mental CIBERSAM, Vitoria, Spain, Rementeria, Lide BIOARABA Hlth Res Inst, Vitoria, Spain, Gonzalez-Pinto, Ana BIOARABA Hlth Res Inst, Vitoria, Spain, Berge, Daniel Hosp del Mar Med Res Inst IMIM, Barcelona, Spain, Berge, Daniel Autonomous Univ Barcelona, Barcelona, Spain, Rodriguez-Jimenez, Roberto Inst Invest Sanitaria Hosp 12 Octubre Imas12, Madrid, Spain, Rodriguez-Jimenez, Roberto Univ Complutense Madrid UCM, CogPsy Grp, Madrid, Spain, Roldan, Alexandra Hosp Santa Creu & Sant Pau, Psychiat Dept, Inst Invest Biomed St Pau IIB ST PAU, Barcelona, Spain, Pomarol-Clotet, Edith FIDMAG Germanes Hosp Res Fdn, Barcelona, Spain, Ibanez, Angela Univ Alcala, Hosp Univ Ramon y Cajal, Dept Psychiat, IRYCIS, Madrid, Spain, Usall, Judith Inst Recerca St Joan de Deu, Teaching Res & Innovat Unit, Parc Sanitari St Joan de Deu, Barcelona, Spain, Garcia-Portilla, Maria Paz Univ Oviedo, Dept Psychiat, Oviedo, Spain, Garcia-Portilla, Maria Paz Inst Invest Sanitaria Principado Asturias ISPA, Oviedo, Principality Of, Spain, Garcia-Portilla, Maria Paz Inst Univ Neurociencias Principado Asturias INEUR, Oviedo, Principality Of, Spain, Garcia-Portilla, Maria Paz Serv Salud Principado Asturias SESPA Oviedo, Oviedo, Spain, Berrocoso, Esther Univ Cadiz, Dept Psychol, Neuropsychopharmacol & Psychobiol Res Grp, Cadiz, Spain, Berrocoso, Esther Hosp Univ Puerta del Mar, Inst Invest & Innovac Biomed Cadiz, INiB, Cadiz, Spain, Carlos III Healthcare Institute, Spanish Ministry of Science, Innovation and Universities, European Regional Development Fund (ERDF/FEDER), Centro de Investigacion Biomedica en Red de Salud Mental (CIBERSAM), CERCA Program, Catalan Government, Secretariat of Universities and Research of the Department of Enterprise and Knowledge, Institut de Neurociencies, Universitat de Barcelona |
| بيانات النشر: | Nature portfolio |
| سنة النشر: | 2022 |
| المجموعة: | Sistema Sanitario Público de Andalucía (SSPA): Repositorio |
| مصطلحات موضوعية: | Leukocyte telomere length, Unaffected siblings, Age, Psychosis |
| الوصف: | The main objective of the present study was to investigate the association between several epigenetic clocks, covering different aspects of aging, with schizophrenia relapse evaluated over a 3-year follow-up period in a cohort of ninety-one first-episode schizophrenia patients. Genome-wide DNA methylation was profiled and four epigenetic clocks, including epigenetic clocks of chronological age, mortality and telomere length were calculated. Patients that relapsed during the follow-up showed epigenetic acceleration of the telomere length clock (p=0.030). Shorter telomere length was associated with cognitive performance (working memory, r=0.31 p=0.015; verbal fluency, r=0.28 p=0.028), but no direct effect of cognitive function or symptom severity on relapse was detected. The results of the present study suggest that epigenetic age acceleration could be involved in the clinical course of schizophrenia and could be a useful marker of relapse when measured in remission stages. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2754-6993 |
| العلاقة: | http://hdl.handle.net/10668/19562Test; https://www.nature.com/articles/s41537-022-00268-2.pdfTest; 928398100001 |
| DOI: | 10.1038/s41537-022-00268-2 |
| الإتاحة: | https://doi.org/10.1038/s41537-022-00268-2Test http://hdl.handle.net/10668/19562Test https://www.nature.com/articles/s41537-022-00268-2.pdfTest |
| حقوق: | Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0Test/ ; open access |
| رقم الانضمام: | edsbas.FF895F9 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 27546993 |
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| DOI: | 10.1038/s41537-022-00268-2 |