دورية أكاديمية
Lymphovascular Space Invasion in Early-Stage Endometrial Cancer (LySEC):Oncological Outcomes, Patterns of Recurrence and Surrogate Markers. A Spanish Gynecologic Oncology Group Study
| العنوان: | Lymphovascular Space Invasion in Early-Stage Endometrial Cancer (LySEC):Oncological Outcomes, Patterns of Recurrence and Surrogate Markers. A Spanish Gynecologic Oncology Group Study |
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| المؤلفون: | Oliver-Perez MR, Padilla Iserte, Pablo, Arencibia-Sanchez O, Martin-Arriscado Arroba, Muruzabal JC, Diaz-Feijóo, Berta, Cabrera, Silvia, Coronado, Pluvio J., Martín-Salamanca MB, Pantoja Garrido, M, Marcos-Sanmartin J, Cabezas-López,E, Lorenzo Cristina, Beric D, Rodriguez-Hernandez,JR, Roldan-Rivas, Gilabert Estelles, Juan, Sanchez,L, Laseca-Modrego M, Tnauste-Rubio CM, Gil-Ibañez, Blanca, Tejerizo-Garcia A. |
| المصدر: | Oliver-Perez MR Padilla Iserte, Pablo Arencibia-Sanchez O Martin-Arriscado Arroba Muruzabal JC Diaz-Feijóo, Berta Cabrera, Silvia Coronado, Pluvio J. Martín-Salamanca MB Pantoja Garrido, M Marcos-Sanmartin J Cabezas-López,E Lorenzo Cristina Beric D Rodriguez-Hernandez,JR Roldan-Rivas Gilabert Estelles, Juan Sanchez,L Laseca-Modrego M Tnauste-Rubio CM Gil-Ibañez, Blanca Tejerizo-Garcia A. 2023 Lymphovascular Space Invasion in Early-Stage Endometrial Cancer (LySEC):Oncological Outcomes, Patterns of Recurrence and Surrogate Markers. A Spanish Gynecologic Oncology Group Study Cancers 15 9 2601 2612 |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2024 |
| المجموعة: | Universitat de València: Roderic - Repositorio de contenido libre |
| مصطلحات موضوعية: | càncer, ginecologia, UNESCO::CIENCIAS MÉDICAS |
| الوصف: | The main aim is to compare oncological outcomes and patterns of recurrence of patients with early-stage endometrioid endometrial cancer according to lymphovascular space invasion (LVSI) status. The secondary objective is to determine preoperative predictors of LVSI. We performed a multicenter retrospective cohort study. A total of 3546 women diagnosed with postoperative early-stage (FIGO I-II, 2009) endometrioid endometrial cancer were included. Co-primary endpoints were disease-free survival (DFS), overall survival (OS), and pattern of recurrence. Cox proportional hazard models were used for time-to-event analysis. Univariate and multivariate logistical regression models were employed. Positive LVSI was identified in 528 patients (14.6%) and was an independent prognostic factor for DFS (HR 1.8), OS (HR 2.1) and distant recurrences (HR 2.37). Distant recurrences were more frequent in patients with positive LVSI (78.2% vs. 61.3%, p < 0.01). Deep myometrial invasion (OR 3.04), high-grade tumors (OR 2.54), cervical stroma invasion (OR 2.01), and tumor diameter ≥ 2 cm (OR 2.03) were independent predictors of LVSI. In conclusion, in these patients, LVSI is an independent risk factor for shorter DFS and OS, and distant recurrence, but not for local recurrence. Deep myometrial invasion, cervical stroma invasion, high-grade tumors, and a tumor diameter ≥ 2 cm are independent predictors of LVSI. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2072-6694 |
| العلاقة: | Cancers, 2023, vol. 15, num. 9, p. 2601-2612; Oliver-Perez, M. R., Padilla-Iserte, P., Arencibia-Sanchez, O., Martin-Arriscado, C., Muruzabal, J. C., Diaz-Feijóo, B., Cabrera, S., Coronado, P., Martín-Salamanca, M. B., Pantoja-Garrido, M., Marcos-Sanmartin, J., Cabezas-López, E., Lorenzo, C., Beric, D., Rodriguez-Hernandez, J. R., Roldan-Rivas, F., Gilabert-Estelles, J., Sanchez, L., … Laseca-Modrego, M. (2023). Lymphovascular Space Invasion in Early-Stage Endometrial Cancer (LySEC): Patterns of Recurrence and Predictors. A Multicentre Retrospective Cohort Study of the Spain Gynecologic Oncology Group. En Cancers (Vol. 15, Issue 9, p. 2612). MDPI AG. https://doi.org/10.3390/cancers15092612Test; https://hdl.handle.net/10550/92142Test; 162384 |
| DOI: | 10.3390/cancers15092612 |
| الإتاحة: | https://doi.org/10.3390/cancers15092612Test https://hdl.handle.net/10550/92142Test |
| حقوق: | open access |
| رقم الانضمام: | edsbas.FF680B85 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20726694 |
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| DOI: | 10.3390/cancers15092612 |